| Substance |
Info | Dose |
Warn | Link |
PubMed |
Latest article |
| Resveratrol | 📋 | ✍ | ⛔ | | 38656259 | Resveratrol mediates mitochondrial function through the sirtuin 3 pathway to improve abnormal metabolic remodeling in atrial fibrillation |
| Curcumin | 📋 | ✍ | ⛔ | | 38723524 | Cardioprotective effects of curcumin against Diabetic Cardiomyopathies: A systematic review and meta-analysis of preclinical studies |
| Ginsenosides | 📋 | ✍ | ⛔ | | 38705107 | Synergistic promotion of angiogenesis after intracerebral hemorrhage by ginsenoside Rh2 and chrysophanol in rats |
| Melatonin | 📋 | ✍ | ⛔ | | 38713551 | Melatonin attenuates renal ischemia-reperfusion injury by regulating mitochondrial dynamics and autophagy through AMPK/DRP1 |
| Vitamin D3 | 📋 | ✍ | ⛔ | | 38672124 | Vitamin D and Cardiovascular Diseases: From Physiology to Pathophysiology and Outcomes |
| Astragalosides | 📋 | ✍ | ⛔ | | 38722470 | Effect of High Magnesium and Astragaloside IV on Vascular Endothelial Cells |
| Omega-3 Fatty Acids | 📋 | ✍ | ⛔ | | 38584606 | New approaches to triglyceride reduction: Is there any hope left? |
| Quercetin | 📋 | ✍ | ⛔ | | 38716618 | Quercetin Ameliorates Myocardial Injury in Diabetic Rats by Regulating Autophagy and Apoptosis through AMPK/mTOR Signaling Pathway |
| Berberine | 📋 | ✍ | ⛔ | | 38639436 | Atorvastatin-induced intracerebral hemorrhage is inhibited by berberine in zebrafish |
| Ginseng | 📋 | ✍ | ⛔ | | 38699996 | Panax notoginseng Saponins Activate Nuclear Factor Erythroid 2-Related Factor 2 to Inhibit Ferroptosis and Attenuate Inflammatory Injury in Cerebral Ischemia-Reperfusion |
| Vitamin C | 📋 | ✍ | ⛔ | | 38664127 | Dietary vitamin C and vitamin E with the risk of aortic aneurysm and dissection: A prospective population-based cohort study |
| Magnesium | 📋 | ✍ | ⛔ | | 38722470 | Effect of High Magnesium and Astragaloside IV on Vascular Endothelial Cells |
| Ginkgo Biloba | 📋 | ✍ | ⛔ | | 38718890 | Efficacy and Safety of Ginkgo biloba Extract in the Treatment of Unstable Angina Pectoris: A Systematic Review and Network Meta-Analysis |
| CoQ10 | 📋 | ✍ | ⛔ | | 38710284 | Coenzyme Q10 mitigates cadmium cardiotoxicity by downregulating NF-κB/NLRP3 inflammasome axis and attenuating oxidative stress in mice |
| EGCG | 📋 | ✍ | ⛔ | | 38574620 | Epigallocatechin-3-gallate confers protection against myocardial ischemia/reperfusion injury by inhibiting ferroptosis, apoptosis, and autophagy via modulation of 14-3-3η |
| Salidroside | 📋 | | | | 38643543 | Salidroside promotes angiogenesis after cerebral ischemia in mice through Shh signaling pathway |
| Puerarin | 📋 | ✍ | ⛔ | | 38381885 | Puerarin protects the fatty liver from ischemia-reperfusion injury by regulating the PI3K/AKT signaling pathway |
| Metformin | 📋 | ✍ | ⛔ | | 38487671 | Metformin Inhibits Autophagy, Mitophagy and Antagonizes Doxorubicin-Induced Cardiomyocyte Death |
| Cocoa | 📋 | ✍ | ⛔ | | 38533262 | New light on changes in the number and function of blood platelets stimulated by cocoa and its products |
| L-Arginine | 📋 | ✍ | ⛔ | | 38428781 | Alleviation of albumin glycation-induced diabetic cardiomyopathy by L-Arginine: Insights into Nrf-2 signaling |
| Salvianolic Acid | 📋 | | | | 38662612 | SALVIANOLIC ACID A ATTENUATES ANGIOTENSIN II-INDUCED CARDIAC FIBROSIS THROUGH REGULATING THE TXNIP SIGNALING PATHWAY |
| Cannabidiol | 📋 | ✍ | ⛔ | | 38401641 | Investigation of neuroprotective and therapeutic effects of cannabidiol in an acute coronary syndrome model |
| Astaxanthin | 📋 | ✍ | ⛔ | | 38537540 | Protective effect of astaxanthin on ANCA-associated vasculitis |
| Hesperidin | 📋 | ✍ | ⛔ | | 38477785 | Protective effects of hesperidin in gastric damage caused by experimental ischemia-reperfusion injury model in rats |
| Vitamin E | 📋 | ✍ | ⛔ | | 38664127 | Dietary vitamin C and vitamin E with the risk of aortic aneurysm and dissection: A prospective population-based cohort study |
| Ginkgolides | 📋 | | | | 38442447 | The anti-apoptotic role of Ginkgolide B via mitochondrial permeability transition pore inhibition in retinal ischemia-reperfusion |
| Luteolin | 📋 | ✍ | ⛔ | | 38077523 | Luteolin Pretreatment Ameliorates Myocardial Ischemia/Reperfusion Injury by lncRNA-JPX/miR-146b Axis |
| Grape Seed extract | 📋 | ✍ | ⛔ | | 37832335 | Grape seed extract in combination with deferasirox ameliorates iron overload, oxidative stress, inflammation, and liver dysfunction in beta thalassemia children |
| Sulforaphane | 📋 | ✍ | ⛔ | | 38203749 | Sulforaphane Is Protective against Warm Ischemia/Reperfusion Injury and Partial Hepatectomy in Rats |
| Apigenin | 📋 | ✍ | ⛔ | | 38141690 | Effect of apigenin on dynamin-related protein 1 in type 1 diabetic rats with cardiovascular complications |
| Selenium | 📋 | ✍ | ⛔ | | 38707461 | Prophylactic zinc and therapeutic selenium administration in adult rats prevents long-term cognitive and behavioral sequelae by a transient ischemic attack |
| Allicin | 📋 | ✍ | ⛔ | | 38460945 | Allicin treats myocardial infarction in I/R through the promotion of the SHP2 axis to inhibit p-PERK-mediated oxidative stress |
| Astragalus Root | 📋 | ✍ | ⛔ | | 38588987 | Mechanism of Astragalus mongholicus Bunge ameliorating cerebral ischemia-reperfusion injury: Based on network pharmacology analysis and experimental verification |
| Lycopene | 📋 | ✍ | ⛔ | | 38301353 | Lycopene inhibits apoptosis of mouse spermatocytes in varicocele via miR-23a/b-induced downregulation of PROK2 |
| N-Acetyl Cysteine | 📋 | ✍ | ⛔ | | 38647950 | N-acetylcysteine Protects Against Myocardial Ischemia-Reperfusion Injury Through Anti-ferroptosis in Type 1 Diabetic Mice |
| Tanshinone | 📋 | | | | 38549714 | Tanshinone IIA Alleviates Traumatic Brain Injury by Reducing Ischemia‒Reperfusion via the miR-124-5p/FoxO1 Axis |
| Pterostilbene | 📋 | ✍ | ⛔ | | 38573589 | EFFECTS OF PTEROSTILBENE ON HEART AND LUNG OXIDATIVE STRESS PARAMETERS IN TWO EXPERIMENTAL MODELS OF CARDIOVASCULAR DISEASE: MYOCARDIAL INFARCTION AND PULMONARY ARTERIAL HYPERTENSION |
| Aged Garlic | 📋 | ✍ | ⛔ | | 38014685 | Interventions to Attenuate Cardiovascular Calcification Progression: A Systematic Review of Randomized Clinical Trials |
| Eicosapentaenoic Acid | 📋 | ✍ | ⛔ | | 38161115 | Effect of omega-3 fatty acids supplementation on the prognosis of coronary artery disease: A meta-analysis of randomized controlled trials |
| Pine Bark | 📋 | ✍ | ⛔ | | 37534931 | Positive effects of Pycnogenol®-Centellicum® on venous elasticity: an ex-vivo concept study |
| Crocin | 📋 | ✍ | ⛔ | | 38113243 | Effect of crocin and treadmill exercise on oxidative stress and heart damage in diabetic rats |
| Diosmin | 📋 | ✍ | ⛔ | | 37629098 | Effect of Diosmin on Selected Parameters of Oxygen Homeostasis |
| Hawthorn | 📋 | ✍ | ⛔ | | 38732560 | Characterizations of White Mulberry, Sea-Buckthorn, Garlic, Lily of the Valley, Motherwort, and Hawthorn as Potential Candidates for Managing Cardiovascular Disease-In Vitro and Ex Vivo Animal Studies |
| Lipoic Acid | 📋 | ✍ | ⛔ | | 38484905 | Impact of combined alpha-lipoic acid and mitoquinone supplementation on myocardial infarction in aged rats: Heart performance and molecular mechanisms |
| Fucoidan | 📋 | ✍ | ⛔ | | 38514926 | Fucoidan suppresses proliferation and epithelial-mesenchymal transition process via Wnt/β-catenin signalling in hemangioma |
| Beets | 📋 | ✍ | ⛔ | | 38572540 | Nitrate ingestion blunts the increase in blood pressure during cool air exposure. A double-blind, placebo-controlled, randomized, crossover trial |
| Citicoline | 📋 | ✍ | ⛔ | | 37489128 | Citicoline May Prevent Cognitive Decline in Patients with Cerebrovascular Disease |
| Naringenin | 📋 | ✍ | ⛔ | | 38516841 | Naringenin Inhibits Acid Sphingomyelinase-Mediated Membrane Raft Clustering to Reduce NADPH Oxidase Activation and Vascular Inflammation |
| Thymoquinone | 📋 | | ⛔ | | 38333755 | Effect of thymoquinone on transient receptor potential melastatin (TRPM) channels in rats with liver ischemia reperfusion model in rats |
| Olive Oil | 📋 | ✍ | ⛔ | | 38568797 | Olive oil intake and cardiovascular disease, cancer, and all-cause mortality: a systematic review and dose-response meta-analysis of prospective cohort studies |
| Rutin | 📋 | ✍ | ⛔ | | 38325842 | Rutin promotes M2 phenotype microglia polarization by suppressing the JAK/STAT3 signaling to protect against retinal ischemia-reperfusion injury |
| Garlic | 📋 | ✍ | ⛔ | | 38732560 | Characterizations of White Mulberry, Sea-Buckthorn, Garlic, Lily of the Valley, Motherwort, and Hawthorn as Potential Candidates for Managing Cardiovascular Disease-In Vitro and Ex Vivo Animal Studies |
| Baicalin | 📋 | ✍ | ⛔ | | 38712979 | Baicalin alleviates angiotensin II-induced cardiomyocyte apoptosis and autophagy and modulates the AMPK/mTOR pathway |
| Food | 📋 | | | | 38713264 | Diet to Stop Hypertension: Should Fats be Included? |
| Genistein | 📋 | ✍ | ⛔ | | 38675531 | Genistein Prevents Apoptosis and Oxidative Stress Induced by Methylglyoxal in Endothelial Cells |
| Nattokinase | 📋 | ✍ | ⛔ | | 38679250 | Nattokinase attenuates endothelial inflammation through the activation of SRF and THBS1 |
| Phytochemicals | 📋 | | | | 38377736 | Targeting the JAK2/STAT3 signaling pathway with natural plants and phytochemical ingredients: A novel therapeutic method for combatting cardiovascular diseases |
| Vitamin B9 | 📋 | ✍ | ⛔ | | 38432716 | Dosage exploration of combined B-vitamin supplementation in stroke prevention: a meta-analysis and systematic review |
| Fisetin | 📋 | ✍ | ⛔ | | 38612535 | Fisetin Alleviates Inflammation and Oxidative Stress in Deep Vein Thrombosis via MAPK and NRF2 Signaling Pathway |
| Micronutrients | 📋 | | ⛔ | | 38380006 | The impact of dietary supplements on blood pressure in older adults: A network meta-analysis of randomized controlled trials |
| NMN | 📋 | ✍ | ⛔ | | 38422177 | Glycolysis-Mediated Activation of v-ATPase by Nicotinamide Mononucleotide Ameliorates Lipid-Induced Cardiomyopathy by Repressing the CD36-TLR4 Axis |
| Red Sage | 📋 | ✍ | ⛔ | | 38641076 | Salvia miltiorrhiza suppresses cardiomyocyte ferroptosis after myocardial infarction by activating Nrf2 signaling |
| Aspirin | 📋 | | ⛔ | | 38560074 | Effect of aspirin on cholesterol crystallization: A potential mechanism for plaque stabilization |
| Goji Berry | 📋 | ✍ | ⛔ | | 38493701 | Lycium barbarum polysaccharide's protective effects against PM2.5-induced cellular senescence in HUVECs |
| Nigella Sativa | 📋 | ✍ | ⛔ | | 37341696 | Antihypertensive effects of Nigella sativa supplementation: An updated systematic review and meta-analysis of randomized controlled trials |
| Andrographolide | 📋 | | | | 38448724 | Andrographolide Improves ApoE4-Mediated Blood-Brain Barrier Injury by Alleviating Inflammation |
| Baicalein | 📋 | ✍ | ⛔ | | 38727775 | Hepatoprotective effects of baicalein against liver ischemia-reperfusion injury and partial hepatectomy in a rat model |
| Ellagic Acid | 📋 | ✍ | ⛔ | | 38584811 | Ellagic acid, a functional food component, ameliorates functionality of reverse cholesterol transport in murine model of atherosclerosis |
| L-Carnitine | 📋 | ✍ | ⛔ | | 38568244 | L-carnitine decreases myocardial injury in children undergoing open-heart surgery: A randomized controlled trial |
| Medicinal Plants | 📋 | | | | 38464786 | The potential of herbal drugs to treat heart failure: The roles of Sirt1/AMPK |
| Pomegranate | 📋 | | ⛔ | | 38410857 | The effects of pomegranate consumption on blood pressure in adults: A systematic review and meta-analysis |
| Gingerol | 📋 | ✍ | | | 38665422 | In vivo protective effects of 6‑gingerol in cerebral ischemia involve preservation of antioxidant defenses and activation of anti‑apoptotic pathways |
| Zinc | 📋 | ✍ | ⛔ | | 38707461 | Prophylactic zinc and therapeutic selenium administration in adult rats prevents long-term cognitive and behavioral sequelae by a transient ischemic attack |
| TUDCA | 📋 | ✍ | ⛔ | | 38518722 | Exploring the impact of high-altitude de-acclimatization on renal function: The roles of oxidative and endoplasmic reticulum stress in rat models |
| Angelica | 📋 | ✍ | ⛔ | | 38731591 | Research Progress in Pharmacological Effects and Mechanisms of Angelica sinensis against Cardiovascular and Cerebrovascular Diseases |
| Nobiletin | 📋 | ✍ | | | 38468335 | Nobiletin alleviates atherosclerosis by inhibiting lipid uptake via the PPARG/CD36 pathway |
| Wenxin Keli | 📋 | ✍ | ⛔ | | 36212955 | Effect of WenXin KeLi on Improvement of Arrhythmia after Myocardial Infarction by Intervening PI3K-AKT-mTOR Autophagy Pathway |
| Anthocyanins | 📋 | ✍ | ⛔ | | 37686067 | Therapeutic Aspects of Prunus cerasus Extract in a Rabbit Model of Atherosclerosis-Associated Diastolic Dysfunction |
| Dihydromyricetin | 📋 | ✍ | ⛔ | | 38596141 | Dihydromyricetin regulates RIPK3-CaMKII to prevent necroptosis in high glucose-stimulated cardiomyocytes |
| Docosahexaenoic Acid | 📋 | ✍ | ⛔ | | 38680033 | Docosahexaenoic Acid Supplementation for Neonatal Hyperbilirubinemia: A Double-Blind, Randomized Clinical Trial |
| Fish Oil | 📋 | ✍ | ⛔ | | 38325778 | Could the association between ozone and arterial stiffness be modified by fish oil supplementation? |
| Naringin | 📋 | ✍ | ⛔ | | 38501506 | Naringin activates semaphorin 3A to ameliorate TGF-β-induced endothelial-to-mesenchymal transition related to atrial fibrillation |
| Gallic Acid | 📋 | | ⛔ | | 38304132 | Gallic Acid Inhibits Proliferation and Migration of Smooth Muscle Cells in a Pig In-Stent Restenosis Model |
| Icariin | 📋 | ✍ | | | 38706972 | Icariin inhibits apoptosis in OGD-induced neurons by regulating M2 pyruvate kinase |
| Moringa Oleifera | 📋 | ✍ | ⛔ | | 37606026 | Evaluating the effectiveness of Moringa oleifera leaf capsules in controlling glycemic and hypertension levels in type 2 diabetes patients |
| Vitamin B12 | 📋 | ✍ | ⛔ | | 38715940 | Functional regulation of microglia by vitamin B12 alleviates ischemic stroke-induced neuroinflammation in mice |
| Coffee | 📋 | ✍ | ⛔ | | 38186410 | Is Coffee and Tea a Threat or Ally to Cardiovascular Health? |
| Kaempferol | 📋 | ✍ | ⛔ | | 38589300 | Effect of Kaempferol on Modulation of Vascular Contractility Mainly through PKC and CPI-17 Inactivation |
| Roselle | 📋 | ✍ | ⛔ | | 38397511 | In Vivo Diuretic Activity and Anti-Hypertensive Potential of Hibiscus sabdariffa Extract by Inhibition of Angiotensin-Converting Enzyme and Hypertension Precursor Enzymes |
| Taurine | 📋 | ✍ | ⛔ | | 38616233 | Taurine ameliorates sensorimotor function by inhibiting apoptosis and activating A2 astrocytes in mice after subarachnoid hemorrhage |
| Chrysin | 📋 | ✍ | ⛔ | | 38555815 | Chrysin inhibits ferroptosis of cerebral ischemia/reperfusion injury via regulating HIF-1α/CP loop |
| Nicotinamide Riboside | 📋 | ✍ | ⛔ | | 38723719 | Nicotinamide riboside alleviates brain dysfunction induced by chronic cerebral hypoperfusion via protecting mitochondria |
| Polyphenols | 📋 | | | | 37998340 | Doxorubicin-Induced Cardiac Senescence Is Alleviated Following Treatment with Combined Polyphenols and Micronutrients through Enhancement in Mitophagy |
| Vitamin K2 | 📋 | ✍ | ⛔ | | 36696048 | Co-supplementation of Vitamin K2 and Selenium Synergistically Improves Metabolic Status and Reduces Cardiovascular Risk Markers in Dyslipidemic Rabbits |
| Asiatic Acid | 📋 | | | | 37717794 | Asiatic acid protects against pressure overload-induced heart failure in mice by inhibiting mitochondria-dependent apoptosis |
| Green Tea | 📋 | ✍ | ⛔ | | 38308353 | Green tea consumption and incidence of cardiovascular disease in type 2 diabetic patients with overweight/obesity: a community-based cohort study |
| Modified Citrus Pectin | 📋 | ✍ | ⛔ | | 38522819 | Effect of modified citrus pectin on galectin-3 inhibition in cisplatin-induced cardiac and renal toxicity |
| Acetyl-L-Carnitine | 📋 | ✍ | ⛔ | | 38155210 | Investigation of the effect of carnitine on cerebral vasospasm in experimental subarachnoid hemorrhage model |
| Hydroxytyrosol | 📋 | | | | 38706564 | Protective effect of hydroxytyrosol and tyrosol metabolites in LPS-induced vascular barrier derangement in vitro |
| L-Citrulline | 📋 | ✍ | ⛔ | | 38338891 | Perinatal Use of Citrulline Rescues Hypertension in Adult Male Offspring Born to Pregnant Uremic Rats |
| Saffron | 📋 | ✍ | ⛔ | | 38207245 | Safety evaluation of saffron extracts in early and established atherosclerotic New Zealand white rabbits |
| Blueberry | 📋 | ✍ | ⛔ | | 37913730 | Protective effects of blueberries on vascular function: A narrative review of preclinical and clinical evidence |
| Geniposide | 📋 | | | | 38614041 | Geniposide ameliorates atherosclerosis by restoring lipophagy via suppressing PARP1/PI3K/AKT signaling pathway |
| Grape | 📋 | | ⛔ | | 35334833 | Grape Pomace Extract Attenuates Inflammatory Response in Intestinal Epithelial and Endothelial Cells: Potential Health-Promoting Properties in Bowel Inflammation |
| Silibinin | 📋 | ✍ | | | 38136238 | Silibinin Inhibits Cell Ferroptosis and Ferroptosis-Related Tissue Injuries |
| Wine | 📋 | | ⛔ | | 38521977 | Is coffee, tea, and red wine consumption beneficial for individuals with hypertension? |
| Emodin | 📋 | | ⛔ | | 38507311 | Emodin ameliorates myocardial fibrosis in mice by inactivating the ROS/PI3K/Akt/mTOR axis |
| Tribulus Terrestris | 📋 | ✍ | ⛔ | | 37876150 | Dietary Supplement with Tribulus terrestris L. Extract Exhibits Protective Effects on Ischemic Stroke Rats |
| Chokeberry | 📋 | ✍ | ⛔ | | 36228567 | The effects of Aronia berry (poly)phenol supplementation on arterial function and the gut microbiome in middle aged men and women: Results from a randomized controlled trial |
| Flavonoids | 📋 | | ⛔ | | 38729253 | Molecular mechanisms of flavonoids in myocardial ischemia reperfusion injury: Evidence from in-vitro and in-vivo studies |
| Mangiferin | 📋 | | ⛔ | | 38094010 | Mangiferin alleviates renal inflammatory injury in spontaneously hypertensive rats by inhibiting MCP-1/CCR2 signaling pathway |
| Paeonol | 📋 | | | | 38593570 | Paeonol can improve hypoxic-induced H9c2 cells injury and ion channel activity by up-regulating the expression of CKIP-1 |
| Reishi Mushrooms | 📋 | ✍ | ⛔ | | 37833299 | Ganoderma lucidum methanolic extract as a potent phytoconstituent: characterization, in-vitro antimicrobial and cytotoxic activity |
| Gotu Kola | 📋 | ✍ | ⛔ | | 38428624 | Intermittent fasting along with hydroalcoholic extract of Centella-asiatica ameliorates sub-acute hypoxia-induced ischemic stroke in adult zebrafish |
| Hesperetin | 📋 | | | | 37866951 | [Hesperetin Alleviates Doxorubicin-Induced Cytotoxicity in H9c2 Cells by Activating SIRT1/NRF2 Signaling] |
| Ollive Leaf extract | 📋 | ✍ | ⛔ | | 38722494 | Simultaneous Exposure to Noise and Toluene Induces Oxidative and Inflammatory Damage in the Heart of Wistar Rats: Therapeutic Potential of Olea europaea L. Leaf Extract |
| Rapamycin | 📋 | ✍ | | | 38224443 | Rapamycin Alleviates Neuronal Injury and Modulates Microglial Activation After Cerebral Ischemia |
| Silymarin | 📋 | ✍ | ⛔ | | 38675181 | Cardioprotective and Hepatoprotective Potential of Silymarin in Paracetamol-Induced Oxidative Stress |
| Chlorogenic Acid | 📋 | ✍ | ⛔ | | 38429854 | Chlorogenic acid regulates the expression of protein phosphatase 2A subunit B in the cerebral cortex of a rat stroke model and glutamate-exposed neurons |
| Crocetin | 📋 | | | | 38675456 | Preventive and Therapeutic Effects of Crocetin in Rats with Heart Failure |
| Ferulic Acid | 📋 | ✍ | ⛔ | | 38223449 | Integrated mass spectrometry imaging reveals spatial-metabolic alteration in diabetic cardiomyopathy and the intervention effects of ferulic acid |
| Ginger | 📋 | ✍ | ⛔ | | 36234956 | Polyphenol-Rich Ginger ( Zingiber officinale) for Iron Deficiency Anaemia and Other Clinical Entities Associated with Altered Iron Metabolism |
| Honokiol | 📋 | | | | 37985436 | Honokiol ameliorates angiotensin II-induced cardiac hypertrophy by promoting dissociation of the Nur77-LKB1 complex and activating the AMPK pathway |
| Arjuna | 📋 | ✍ | ⛔ | | 38555178 | Effectiveness of herbal drug Terminalia Arjuna in chronic venous insufficiency - A prospective observational study |
| Vitamin B6 | 📋 | ✍ | ⛔ | | 38432716 | Dosage exploration of combined B-vitamin supplementation in stroke prevention: a meta-analysis and systematic review |
| Calycosin | 📋 | | | | 38576421 | Exploring the effects of calycosin on anthracycline-induced cardiotoxicity: a network pharmacology, molecular docking, and experimental study |
| Capsaicin | 📋 | ✍ | ⛔ | | 38524547 | Potential actions of capsaicin for preventing vascular calcification of vascular smooth muscle cells in vitro and in vivo |
| Green Tea Polyphenols | 📋 | ✍ | ⛔ | | 38328786 | A randomized placebo-controlled clinical trial of oral green tea epigallocatechin 3-gallate on erythropoiesis and oxidative stress in transfusion-dependent β-thalassemia patients |
| Schisandra | 📋 | ✍ | ⛔ | | 37006723 | Investigating the Mechanism of Action of Schisandra chinensis Combined with Coenzyme Q10 in the Treatment of Heart Failure Based on PI3K-AKT Pathway |
| Walnut | 📋 | | ⛔ | | 36213224 | Walnut supplementation after fructose-rich diet is associated with a beneficial fatty acid ratio and increased ACE2 expression in the rat heart |
| Acacetin | 📋 | | | | 38114218 | [Acacetin protects rats from cerebral ischemia-reperfusion injury by regulating TLR4/NLRP3 signaling pathway] |
| Almond | 📋 | | ⛔ | | 36331011 | The effect of almond intake on cardiometabolic risk factors, inflammatory markers, and liver enzymes: A systematic review and meta-analysis |
| Dihydroquercetin | 📋 | | | | 38053888 | Taxifolin protects against doxorubicin-induced cardiotoxicity and ferroptosis by adjusting microRNA-200a-mediated Nrf2 signaling pathway |
| Formononetin | 📋 | | | | 38528555 | Formononetin reverses Treg/Th17 imbalance in immune-mediated bone marrow failure mice by regulating the PI3K/Akt signaling pathway |
| Papaya | 📋 | ✍ | ⛔ | | 36119216 | Effect of doxycycline and doxycycline with carica papaya on thrombocytopenia and leucopenia in acute dengue fever patients |
| Piperine | 📋 | ✍ | ⛔ | | 38484898 | Piperine attenuates hepatic ischemia/reperfusion injury via suppressing the TLR4 signaling cascade in mice |
| Shensong Yangxin | 📋 | ✍ | | | 38305401 | The Different Therapeutic Effects of Traditional Chinese Medicine Shensong Yangxin Capsule and Salubrinal in High-intensity Exercise-induced Heart Failure in Rats with Acute Myocardial Infarction |
| Vitamin K | 📋 | ✍ | ⛔ | | 38137375 | Vitamin K and Calcium Chelation in Vascular Health |
| Carvacrol | 📋 | ✍ | ⛔ | | 38726397 | Protective effects of carvacrol on lipid profiles, oxidative stress, hypertension, and cardiac dysfunction - A comprehensive review |
| L-Glutamine | 📋 | ✍ | ⛔ | | 38401036 | A Population Pharmacokinetic Analysis of L-Glutamine Exposure in Patients with Sickle Cell Disease: Evaluation of Dose and Food Effects |
| Mulberry | 📋 | | ⛔ | | 38732560 | Characterizations of White Mulberry, Sea-Buckthorn, Garlic, Lily of the Valley, Motherwort, and Hawthorn as Potential Candidates for Managing Cardiovascular Disease-In Vitro and Ex Vivo Animal Studies |
| Oleuropein | 📋 | | | | 38589925 | Oleuropein alleviates myocardial ischemia-reperfusion injury by suppressing oxidative stress and excessive autophagy via TLR4/MAPK signaling pathway |
| Punicalagin | 📋 | ✍ | ⛔ | | 37806379 | Punicalagin attenuates myocardial oxidative damage, inflammation, and apoptosis in isoproterenol-induced myocardial infarction in rats: Biochemical, immunohistochemical, and in silico molecular docking studies |
| Acai Berry | 📋 | ✍ | ⛔ | | 37626388 | Euterpe oleracea extract (açaÃ) exhibits cardioprotective effects after chemotherapy treatment in a breast cancer model |
| Cinnamon | 📋 | ✍ | ⛔ | | 37240821 | The Anti-Cancer Effect of Cinnamon Aqueous Extract: A Focus on Hematological Malignancies |
| Galangin | 📋 | | | | 38293976 | [Galangin inhibits oxidized low-density lipoprotein-induced angiogenic activity in human aortic endothelial cells by downregulating lncRNA H19] |
| Paeoniflorin | 📋 | | | | 38427210 | Paeoniflorin attenuates cuproptosis and ameliorates left ventricular remodeling after AMI in hypobaric hypoxia environments |
| Red Yeast Rice | 📋 | ✍ | ⛔ | | 38283922 | Evaluation of the effect of a dietary supplementation with a red yeast rice and fish oil-containing nutraceutical on lipid pattern, high sensitivity C-reactive protein, and endothelial function in moderately hypercholesterolaemic subjects: a double-blind, placebo-controlled, randomized clinical trial |
| Rosmarinic Acid | 📋 | ✍ | | | 38373191 | Rosmarinic Acid Activates the Nrf2/ARE Signaling Pathway via the miR-25-3p/SIRT6 Axis to Inhibit Vascular Remodeling |
| Spirulina | 📋 | ✍ | ⛔ | | 38474769 | Beneficial Effects of Spirulina Supplementation in the Management of Cardiovascular Diseases |
| Tea | 📋 | | | | 38604951 | [Association between habitual tea consumption and 10-year cardiovascular risk among Chinese mid-aged and elderly] |
| Alpha-Linolenic Acid | 📋 | ✍ | ⛔ | | 38117698 | Association between dietary omega-3 intake and coronary heart disease among American adults: The NHANES, 1999-2018 |
| Cinnamaldehyde | 📋 | | | | 38404216 | Cinnamaldehyde protects cardiomyocytes from oxygen-glucose deprivation/reoxygenation-induced lipid peroxidation and DNA damage via activating the Nrf2 pathway |
| DHEA | 📋 | ✍ | ⛔ | | 37391895 | Serum DHEA and Testosterone Levels Associate Inversely with Coronary Artery Calcification in Elderly Men |
| Escin | 📋 | ✍ | ⛔ | | 37716034 | Escin avoids hemorrhagic transformation in ischemic stroke by protecting BBB through the AMPK/Cav-1/MMP-9 pathway |
| Schisandrins | 📋 | | | | 38285214 | Schizandrin A attenuates early brain injury following subarachnoid hemorrhage through suppressing neuroinflammation |
| Spikenard | 📋 | ✍ | ⛔ | | 36408810 | Total saponins of Aralia elata (Miq.) Seem. alleviate myocardial ischemia-reperfusion injury by promoting NLRP3-inflammasome inactivation via PI3K/Akt signaling |
| Arctigenin | 📋 | | | | 37381960 | [Arctigenin mitigates vascular endothelial injury in rats with pregnancy-induced hypertension via autophagy-NLRP3 inflammasome pathway] |
| Bee Propolis | 📋 | ✍ | ⛔ | | 38556227 | Propolis in the management of cardiovascular disease |
| Glycyrrhizic Acid | 📋 | ✍ | ⛔ | | 38185229 | Glycyrrhizic acid alleviated MI/R-induced injuries by inhibiting Hippo/YAP signaling pathways |
| Scutellarin | 📋 | | | | 38382550 | Scutellarin inhibits oleic acid induced vascular smooth muscle foam cell formation via activating autophagy and inhibiting NLRP3 inflammasome activation |
| Vitamin B3 | 📋 | ✍ | ⛔ | | 38186996 | Niacin increases human aortic endothelial Sirt1 activity and nitric oxide: effect on endothelial function and vascular aging |
| Antioxidants | 📋 | | ⛔ | | 38540114 | Novel Multi-Antioxidant Approach for Ischemic Stroke Therapy Targeting the Role of Oxidative Stress |
| Artemisinin | 📋 | | | | 38258596 | Artemisinin Attenuates Isoproterenol-induced Cardiac Hypertrophy via the ERK1/2 and p38 MAPK Signaling Pathways |
| Black Tea | 📋 | ✍ | ⛔ | | 38161525 | Impact of Green Tea Consumption on the Prevalence of Cardiovascular Outcomes: A Systematic Review |
| Folate | 📋 | ✍ | ⛔ | | 37707697 | Folic Acid and Folinic Acid Protect Hearts of Aging Triple-transgenic Alzheimer's Disease mice via IGF1R/PI3K/AKT and SIRT1/AMPK Pathways |
| Irisin | 📋 | | | | 38663105 | New insights into the roles of Irisin in diabetic cardiomyopathy and vascular diseases |
| Kudzu Root | 📋 | ✍ | ⛔ | | 38048301 | Effect of pueraria on left ventricular remodelling in HFrEF: A systematic review and meta-analysis |
| Senolytics | 📋 | | | | 38680957 | Cellular Senescence as a Targetable Risk Factor for Cardiovascular Diseases: Therapeutic Implications: JACC Family Series |
| Trehalose | 📋 | | ⛔ | | 38433753 | Trehalose promotes atherosclerosis regression in female mice |
| Wogonin | 📋 | ✍ | ⛔ | | 38253131 | Wogonin alleviates NLRP3 inflammasome activation after cerebral ischemia-reperfusion injury by regulating AMPK/SIRT1 |
| Apple | 📋 | | ⛔ | | 35499960 | Associations between fruit consumption and home blood pressure in a randomly selected sample of the general Swedish population |
| Asiaticoside | 📋 | | | | 38597444 | [Effect of asiaticoside on systolic blood pressure and relaxation of isolated thoracic aorta of rats] |
| Bergamot | 📋 | ✍ | ⛔ | | 38242036 | The protective effect of Bergamot Polyphenolic Fraction on reno-cardiac damage induced by DOCA-salt and unilateral renal artery ligation in rats |
| Indian Gooseberry | 📋 | | ⛔ | | 37296402 | Clinical effects of Emblica officinalis fruit consumption on cardiovascular disease risk factors: a systematic review and meta-analysis |
| Ligustilide | 📋 | | | | 35512628 | Ligustilide ameliorates hippocampal neuronal injury after cerebral ischemia reperfusion through activating PINK1/Parkin-dependent mitophagy |
| Myricetin | 📋 | | ⛔ | | 38472186 | Myricetin alleviates diabetic cardiomyopathy by regulating gut microbiota and their metabolites |
| Nuts | 📋 | | ⛔ | | 38254543 | The Cardioprotective Properties of Selected Nuts: Their Functional Ingredients and Molecular Mechanisms |
| Carotenoids | 📋 | ✍ | ⛔ | | 38303096 | Association between dietary carotenoid intakes and abdominal aortic calcification in adults: National Health and Nutrition Examination Survey 2013-2014 |
| Catalpol | 📋 | | | | 38522312 | Catalpol attenuates ischemic stroke by promoting neurogenesis and angiogenesis via the SDF-1α/CXCR4 pathway |
| Catechins | 📋 | | | | 37150886 | (+)-catechin attenuates multiple atherosclerosis-associated processes in vitro, modulates disease-associated risk factors in C57BL/6J mice and reduces atherogenesis in LDL receptor deficient mice by inhibiting inflammation and increasing markers of plaque stability |
| Daidzein | 📋 | ✍ | ⛔ | | 38477605 | Daidzein protects endothelial cells against high glucose-induced injury through the dual-activation of PPARα and PPARγ |
| Fish | 📋 | | ⛔ | | 38676880 | Omega-3 Fatty Acids and Risk of Ischemic Stroke in REGARDS |
| Licorice Root | 📋 | ✍ | ⛔ | | 37308027 | Anti-arrhythmia potential of honey-processed licorice in zebrafish model: Antioxidant, histopathological and tissue distribution |
| Metoprolol | 📋 | ✍ | ⛔ | | 37122993 | Evaluation of metoprolol standard dosing pathway in Chinese patients with acute coronary syndrome: a prospective multicenter single-arm interventional study |
| NAD | 📋 | | | | 38357951 | The Role of NAD+ in Myocardial Ischemia-induced Heart Failure in Sprague-Dawley Rats and Beagles |
| Pomegranate Peel extract | 📋 | ✍ | ⛔ | | 37376144 | Pomegranate Peel Extract Attenuates Isoprenaline-Induced Takotsubo-like Myocardial Injury in Rats |
| Boswellic Acid | 📋 | ✍ | ⛔ | | 37230158 | Novel synergistic mechanism of 11-keto-β-boswellic acid and Z-Guggulsterone on ischemic stroke revealed by single-cell transcriptomics |
| Caffeine | 📋 | ✍ | ⛔ | | 38057002 | The effects of caffeine supplementation on blood pressure in adults: A systematic review and dose-response meta-analysis |
| Orange | 📋 | | ⛔ | | 37469434 | Blood orange juice intake changes specific bacteria of gut microbiota associated with cardiometabolic biomarkers |
| Retinoic Acid | 📋 | | | | 37166528 | All-trans retinoic acid added to treatment of primary immune thrombocytopenia: a systematic review and meta-analysis |
| Safflower | 📋 | ✍ | ⛔ | | 38036060 | Uncovering Mechanism and Efficacy of Salvia Miltiorrhiza-Safflower in Cerebral Ischemia-Reperfusion Injury |
| Sea Buckthorn | 📋 | ✍ | ⛔ | | 38732560 | Characterizations of White Mulberry, Sea-Buckthorn, Garlic, Lily of the Valley, Motherwort, and Hawthorn as Potential Candidates for Managing Cardiovascular Disease-In Vitro and Ex Vivo Animal Studies |
| Strawberry | 📋 | ✍ | ⛔ | | 36112603 | Gut Microbes are Associated with the Vascular Beneficial Effects of Dietary Strawberry on Metabolic Syndrome-Induced Vascular Inflammation |
| Tomato | 📋 | | ⛔ | | 38001046 | Association between tomato consumption and blood pressure in an older population at high cardiovascular risk: observational analysis of PREDIMED trial |
| Cordycepin | 📋 | | | | 37634411 | Pharmacological and therapeutic potentials of cordycepin in hematological malignancies |
| Fucoxanthin | 📋 | ✍ | ⛔ | | 37965135 | Fucoxanthin ameliorates traumatic brain injury by suppressing the blood-brain barrier disruption |
| Iron | 📋 | ✍ | ⛔ | | 37722377 | Iron deficiency in myocardial ischemia: molecular mechanisms and therapeutic perspectives |
| Probiotics | 📋 | ✍ | ⛔ | | 38472752 | Oral Administration of Fermented Milk from Co-Starter Containing Lactobacillus plantarum Y44 Shows an Ameliorating Effect on Hypertension in Spontaneously Hypertensive Rats |
| Telmisartan | 📋 | | ⛔ | | 38180364 | [Telmisartan chronotherapy and its influence on the indicators of the daily profile blood pressure] |
| Vitamin K2 mk-7 | 📋 | ✍ | | | 37299386 | Effect of Menaquinone-7 Supplementation on Arterial Stiffness in Chronic Hemodialysis Patients: A Multicenter Randomized Controlled Trial |
| Whey Protein | 📋 | ✍ | ⛔ | | 38174000 | Protein supplementation: the double-edged sword |
| Burdock | 📋 | | ⛔ | | 38669967 | Ethanolic extract of Arctium lappa leaves alleviates cerebral ischemia reperfusion-induced inflammatory injury via HDAC9-mediated NF-κB pathway |
| Eugenol | 📋 | | | | 38719078 | Effect of Intrathecal Eugenol on Cerebral Vasospasm in an Experimental Subarachnoid Hemorrhage Model |
| L-Carnosine | 📋 | ✍ | ⛔ | | 38348353 | Iron scavenging and suppression of collagen cross-linking underlie antifibrotic effects of carnosine in the heart with obesity |
| Liquiritin | 📋 | | | | 38361515 | Mechanistic investigation of the ameliorative effect of liquiritin on hypoxia/reoxygenation‑induced cardiomyocyte injury based on network pharmacology and in vitro validation |
| Nitrate | 📋 | ✍ | ⛔ | | 38472804 | The Cardioprotective Role of Nitrate-Rich Vegetables |
| PUFA | 📋 | | | | 37753192 | Association of dietary fatty acid intake with hypertension in children and adolescents: evidence from the NHANES 2005-2018 |
| Vitamin A | 📋 | ✍ | ⛔ | | 36399384 | Vitamin A Preserves Cardiac Energetic Gene Expression in a Murine Model of Diet-Induced Obesity |
| Bilobalide | 📋 | | | | 37199885 | Bilobalide Prevents Apoptosis and Improves Cardiac Function in Myocardial Infarction |
| Cherry | 📋 | | ⛔ | | 36771387 | Dark Sweet Cherry ( Prunus avium) Supplementation Reduced Blood Pressure and Pro-Inflammatory Interferon Gamma (IFNγ) in Obese Adults without Affecting Lipid Profile, Glucose Levels and Liver Enzymes |
| Dandelion | 📋 | ✍ | ⛔ | | 37836404 | Dandelion Polysaccharides Ameliorate High-Fat-Diet-Induced Atherosclerosis in Mice through Antioxidant and Anti-Inflammatory Capabilities |
| Dioscin | 📋 | | | | 38672439 | Protective Role of Dioscin against Doxorubicin-Induced Chronic Cardiotoxicity: Insights from Nrf2-GPX4 Axis-Mediated Cardiac Ferroptosis |
| Diosmetin | 📋 | | | | 37367046 | Antioxidant Flavonoid Diosmetin Is Cardioprotective in a Rat Model of Myocardial Infarction Induced by Beta 1-Adrenergic Receptors Activation |
| Flaxseed Oil | 📋 | ✍ | ⛔ | | 37778442 | Effect of alpha-linolenic acid supplementation on cardiovascular risk profile in individuals with obesity or overweight: A systematic review and meta-analysis of randomized controlled trials |
| Fruits | 📋 | | | | 38068771 | Vegetable and Fruit Intake Variety and Cardiovascular Health and Mortality: A Systematic Review and Meta-Analysis of Observational Studies |
| Lemon Balm | 📋 | ✍ | ⛔ | | 35890139 | Short-Term Administration of Lemon Balm Extract Ameliorates Myocardial Ischemia/Reperfusion Injury: Focus on Oxidative Stress |
| Lutein | 📋 | ✍ | ⛔ | | 37797674 | Lutein suppresses ferroptosis of cardiac microvascular endothelial cells via positive regulation of IRF in cardiac hypertrophy |
| Polydatin | 📋 | ✍ | | | 37783713 | Polydatin improves vascular endothelial function by maintaining mitochondrial homeostasis under high glucose conditions |
| Raspberry | 📋 | ✍ | ⛔ | | 38628181 | The effects of raspberry consumption on lipid profile and blood pressure in adults: A systematic review and meta-analysis |
| Tangeretin | 📋 | | | | 38074289 | Tangeretin confers neuroprotection, cognitive and memory enhancement in global cerebral ischemia in rats |
| Apple Polyphenols | 📋 | | ⛔ | | 37824601 | Apple Polyphenol Extract Ameliorates Atherosclerosis and Associated Cognitive Impairment through Alleviating Neuroinflammation by Weakening TLR4 Signaling and NLRP3 Inflammasome in High-Fat/Cholesterol Diet-Fed LDLR-/- Male Mice |
| Beta-Sitosterol | 📋 | ✍ | ⛔ | | 38028434 | Inhibitory Effect of β-Sitosterol on the Ang II-Induced Proliferation of A7r5 Aortic Smooth Muscle Cells |
| Cheese | 📋 | | ⛔ | | 38161113 | Cheese consumption on atherosclerosis, atherosclerotic cardiovascular diseases and its complications: A two-sample Mendelian randomization study |
| Chrysanthemum | 📋 | ✍ | ⛔ | | 37237885 | Hydrogen Protection Boosts the Bioactivity of Chrysanthemum morifolium Extract in Preventing Palmitate-Induced Endothelial Dysfunction by Restoring MFN2 and Alleviating Oxidative Stress in HAEC Cells |
| Coconut Oil | 📋 | | ⛔ | | 37397927 | Cardioprotective role of the coenzyme Q10 and coconut oil in acute aluminum phosphide poisoning: a randomized controlled clinical trial |
| Fiber | 📋 | ✍ | ⛔ | | 38586958 | Recommendations for the Use of Dietary Fiber to Improve Blood Pressure Control |
| Flaxseed | 📋 | ✍ | ⛔ | | 37778442 | Effect of alpha-linolenic acid supplementation on cardiovascular risk profile in individuals with obesity or overweight: A systematic review and meta-analysis of randomized controlled trials |
| Nuciferine | 📋 | | | | 38528077 | Nuciferine reduces vascular leakage and improves cardiac function in acute myocardial infarction by regulating the PI3K/AKT pathway |
| Peanut | 📋 | | ⛔ | | 35337573 | Peanut skin extract ameliorates high-fat diet-induced atherosclerosis by regulating lipid metabolism, inflammation reaction and gut microbiota in ApoE -/- mice |
| Rhodiola | 📋 | ✍ | ⛔ | | 38505080 | Investigating the multitarget pharmacological mechanism of Rhodiola wallichiana var. cholaensis acting on angina pectoris using combined network pharmacology and molecular docking |
| Vitamin B1 | 📋 | ✍ | ⛔ | | 37959269 | Reduction in Arterial Stiffness Index (SI) in Response to Combination Antioxidant Therapy |
| Vitamin B2 | 📋 | ✍ | ⛔ | | 37377111 | Riboflavin protects against heart failure via SCAD-dependent DJ-1- Keap1-Nrf2 signaling pathway |
| Vitexin | 📋 | | | | 38299432 | Protective Effect of Vitexin Against IL-17-Induced Vascular Endothelial Inflammation Through Keap1/Nrf2-Dependent Signaling Pathway |
| Zingerone | 📋 | | | | 37240920 | Trastuzumab-Mediated Cardiotoxicity and Its Preventive Intervention by Zingerone through Antioxidant and Inflammatory Pathway in Rats |
| Aloe-Emodin | 📋 | | | | 38621328 | Aloe-emodin alleviates cerebral ischemia-reperfusion injury by regulating microglial polarization and pyroptosis through inhibition of NLRP3 inflammasome activation |
| Beta-Carotene | 📋 | ✍ | ⛔ | | 38319073 | β-Carotene accelerates the resolution of atherosclerosis in mice |
| Cardamom | 📋 | ✍ | ⛔ | | 38593657 | Cardamom consumption may improve cardiovascular metabolic biomarkers in adults: A systematic review and meta-analysis of randomized controlled trials |
| Choline | 📋 | ✍ | ⛔ | | 38711145 | Dietary choline intake and health outcomes in U.S. adults: exploring the impact on cardiovascular disease, cancer prevalence, and all-cause mortality |
| Geraniol | 📋 | | | | 38446318 | Geraniol attenuates oxygen-glucose deprivation/reoxygenation-induced ROS-dependent apoptosis and permeability of human brain microvascular endothelial cells by activating the Nrf-2/HO-1 pathway |
| Hyperoside | 📋 | | | | 38722076 | Study on the hypotensive effect and mechanism of hawthorn (Crataegus pinnatifida) fruits and hyperoside in spontaneously hypertensive rats |
| Neferine | 📋 | | | | 38526658 | Neferine Pretreatment Attenuates Isoproterenol-Induced Cardiac Injury Through Modulation of Oxidative Stress, Inflammation, and Apoptosis in Rats |
| Nicotinamide | 📋 | ✍ | ⛔ | | 37775016 | Nicotinamide, an acetylcholinesterase uncompetitive inhibitor, protects the blood‒brain barrier and improves cognitive function in rats fed a hypercaloric diet |
| Olive Polyphenols | 📋 | | | | 36364796 | Neuroprotective Panel of Olive Polyphenols: Mechanisms of Action, Anti-Demyelination, and Anti-Stroke Properties |
| Peony | 📋 | | ⛔ | | 38281062 | Efficacy of a mixed extract of Salvia miltiorrhiza and Paeonia lactiflora in inhibiting the aging of vascular wall through in vitro and in vivo experiments |
| Potassium | 📋 | ✍ | ⛔ | | 38163867 | Effect of low sodium and high potassium diet on lowering blood pressure and cardiovascular events |
| Shogaol | 📋 | | | | 37432400 | 6-Shogaol, an Active Component of Ginger, Inhibits p300 Histone Acetyltransferase Activity and Attenuates the Development of Pressure-Overload-Induced Heart Failure |
| Tannic Acid | 📋 | ✍ | ⛔ | | 34562517 | Tannic acid protects aged brain against cerebral hypoperfusion via modulation of Nrf2 and inflammatory pathways |
| Urolithins | 📋 | | | | 38360072 | Intestinal metabolite UroB alleviates cerebral ischemia/reperfusion injury by promoting competition between TRIM65 and TXNIP for binding to NLRP3 inflammasome in response to neuroinflammation |
| Vitamin K1 | 📋 | ✍ | ⛔ | | 38342722 | Vitamin K1 intake is associated with lower risk for all-cause and cardiovascular disease mortality in community-dwelling older Australian women |
| Andrographis | 📋 | ✍ | ⛔ | | 37930331 | Andrographolide Attenuates Oxidized LDL-Induced Activation of the NLRP3 Inflammasome in Bone Marrow-Derived Macrophages and Mitigates HFCCD-Induced Atherosclerosis in Mice |
| Argan Oil | 📋 | ✍ | ⛔ | | 30153577 | A comparative study on the effect of argan oil versus fish oil on risk factors for cardio-vascular disease in high-fat-fed rats |
| Caffeic Acid | 📋 | ✍ | ⛔ | | 37833536 | Caffeic acid alleviates cerebral ischemic injury in rats by resisting ferroptosis via Nrf2 signaling pathway |
| Carnosic Acid | 📋 | | | | 38419896 | Carnosic acid mitigates doxorubicin-induced cardiac toxicity: Evidence from animal and cell model investigations |
| Coptis Chinensis | 📋 | | ⛔ | | 37499457 | Identification of bioactive compounds and potential mechanisms of scutellariae radix-coptidis rhizoma in the treatment of atherosclerosis by integrating network pharmacology and experimental validation |
| Cordyceps | 📋 | ✍ | ⛔ | | 38494355 | Cordyceps as potential therapeutic agents for atherosclerosis |
| Evening Primrose Oil | 📋 | ✍ | ⛔ | | 35791734 | Supplementation with omega-3 or omega-6 fatty acids attenuates platelet reactivity in postmenopausal women |
| Frankincense | 📋 | ✍ | ⛔ | | 38078787 | In Silico Exploration of Potential Phytoconstituents from the Bark Extract of Boswellia serrata for Hemorrhoidal Disease: Molecular Docking and Molecular Dynamics Analysis |
| Ginkgetin | 📋 | | | | 38334198 | Ginkgetin effectively mitigates collagen and AA-induced platelet activation via PLCγ2 but not cyclic nucleotide-dependent pathway in human |
| Icaritin | 📋 | | | | 38224965 | Icaritin sensitizes thrombin- and TxA2-induced platelet activation and promotes hemostasis via enhancing PLCγ2-PKC signaling pathways |
| Isoliquiritigenin | 📋 | | | | 38395608 | Isoliquiritigenin attenuates neuroinflammation after subarachnoid hemorrhage through inhibition of NF-κB-mediated NLRP3 inflammasome activation |
| Kiwifruit | 📋 | ✍ | ⛔ | | 35807858 | Metabolic and Blood Pressure Effects of Consuming Two Kiwifruit Daily for 7 Weeks: A Randomised Controlled Trial |
| Linoleic Acid | 📋 | ✍ | ⛔ | | 37803087 | Replacement of saturated fatty acids with linoleic acid in western diet attenuates atherosclerosis in a mouse model with inducible ablation of hepatic LDL receptor |
| Persimmon | 📋 | | ⛔ | | 37115470 | Therapeutic effects of a standardized-flavonoid Diospyros kaki L.f. leaf extract on transient focal cerebral ischemia-induced brain injury in mice |
| Procyanidins | 📋 | | ⛔ | | 37885736 | Protective effect and mechanism of procyanidin B2 against hypoxic injury of cardiomyocytes |
| Spermidine | 📋 | | | | 38293988 | [Spermidine alleviates lipopolysaccharide-induced myocardial injury in mice by suppressing apoptosis, ROS production and ferroptosis] |
| Stinging Nettle | 📋 | ✍ | ⛔ | | 35189251 | Exercise and Urtica Dioica extract ameliorate mitochondrial function and the expression of cardiac muscle Nuclear Respiratory Factor 2 and Peroxisome proliferator-activated receptor Gamma Coactivator 1-alpha in STZ-induced diabetic rats |
| Turmeric | 📋 | ✍ | ⛔ | | 35525529 | Vasorelaxant effect of curcubisabolanin A isolated from Curcuma longa through the PI3K/Akt/eNOS signaling pathway |
| Withaferin A | 📋 | | | | 38727319 | Withaferin A as a Potential Therapeutic Target for the Treatment of Angiotensin II-Induced Cardiac Cachexia |
| Amygdalin | 📋 | ✍ | ⛔ | | 38529199 | Beneficial role of amygdalin extracts against animal growth regulator Boldjan induced cardiac toxicity, injury and oxidative stress in male rats |
| Ashwagandha | 📋 | ✍ | ⛔ | | 34090907 | Standardized root extract of Withania somnifera and Withanolide A exert moderate vasorelaxant effect in the rat aortic rings by enhancing nitric oxide generation |
| Bee Venom | 📋 | ✍ | ⛔ | | 37153087 | Clinical and histopathological responses to bee venom phonophoresis in treating venous and diabetic ulcers: a single-blind randomized controlled trial |
| Berries | 📋 | | | | 35300756 | Effects of Anthocyanin-rich Berries on the Risk of Metabolic Syndrome: A Systematic Review and Meta-analysis |
| CAPE | 📋 | | | | 38474755 | Ethanolic Extract of Propolis and CAPE as Cardioprotective Agents against LPS and IFN-α Stressed Cardiovascular Injury |
| Coriander | 📋 | | ⛔ | | 37518878 | Effects of Coriandrum sativum on distant organ inflammation and apoptosis due to liver ischemia/reperfusion injury |
| Cranberry | 📋 | ✍ | ⛔ | | 37823158 | The role of alcohol extract of cranberry in improving serum indices of experimental metaproterenol-induced heart damage in rats |
| Date | 📋 | | ⛔ | | 35268000 | Methanolic Phoenix dactylifera L. Extract Ameliorates Cisplatin-Induced Hepatic Injury in Male Rats |
| Fo-Ti Root | 📋 | ✍ | ⛔ | | 38623977 | Exploring the Constituents and Mechanisms of Polygonum multiflorum Thunb. in Mitigating Ischemic Stroke: A Network Pharmacology and Molecular Docking Study |
| Ginger extract | 📋 | ✍ | ⛔ | | 38123793 | A ginger extract improves ocular blood flow in rats with endothelin-induced retinal blood flow dysfunction |
| Lavender Essential Oil | 📋 | ✍ | ⛔ | | 38087747 | Effect of Lavandula angustifolia and Cananga odorata on decrease of blood pressure in high blood pressure volunteers: A randomized controlled trial |
| Lotus | 📋 | | ⛔ | | 36278191 | Study on the vasodilatory activity of lotus leaf extract and its representative substance nuciferine on thoracic aorta in rats |
| Magnolol | 📋 | | | | 37074505 | Cardioprotective role of a magnolol and honokiol complex in the prevention of doxorubicin-mediated cardiotoxicity in adult rats |
| Mangosteen | 📋 | ✍ | ⛔ | | 35904170 | The metabolic and molecular mechanisms of α‑mangostin in cardiometabolic disorders (Review) |
| Onion | 📋 | ✍ | ⛔ | | 34400937 | Onion ( Allium cepa) and its Main Constituents as Antidotes or Protective Agents against Natural or Chemical Toxicities: A Comprehensive Review |
| Sesamin | 📋 | ✍ | | | 37357850 | Sesamin suppresses angiotensin-II-enhanced oxidative stress and hypertrophic markers in H9c2 cells |
| Theaflavins | 📋 | ✍ | | | 38171247 | Theaflavin pretreatment ameliorates renal ischemia/reperfusion injury by attenuating apoptosis and oxidative stress in vivo and in vitro |
| Trans-Resveratrol | 📋 | | | | 36358483 | Markers of Endothelial Dysfunction Are Attenuated by Resveratrol in Preeclampsia |
| Vegetables | 📋 | | | | 38068771 | Vegetable and Fruit Intake Variety and Cardiovascular Health and Mortality: A Systematic Review and Meta-Analysis of Observational Studies |
| Aloin | 📋 | | | | 34801516 | Aloin alleviates pathological cardiac hypertrophy via modulation of the oxidative and fibrotic response |
| Anethole | 📋 | | | | 36986541 | Anethole Pretreatment Modulates Cerebral Ischemia/Reperfusion: The Role of JNK, p38, MMP-2 and MMP-9 Pathways |
| Barberry | 📋 | ✍ | ⛔ | | 36910359 | Berberis lyceum root bark extract attenuates anticancer drugs induced neurotoxicity and cardiotoxicity in rats |
| Betaine | 📋 | ✍ | ⛔ | | 38703273 | Betaine Protects Mice from Cardiotoxicity Triggered by Sodium Arsenite Through Antioxidative and Anti-inflammatory Pathways |
| Biochanin A | 📋 | | | | 38476892 | Biochanin A inhibits endothelial dysfunction induced by IL‑6‑stimulated endothelial microparticles in Perthes disease via the NFκB pathway |
| Camellia | 📋 | | ⛔ | | 36660600 | Camellia oil ( Camellia oleifera Abel.) treatment improves high-fat diet-induced atherosclerosis in apolipoprotein E (ApoE)-/- mice |
| Captopril | 📋 | | | | 38607208 | Correlation Between the Severity of Coronary Artery Disease and Retinal Artery Disease and the Therapeutic Effect of Captopril |
| Chlorella | 📋 | ✍ | ⛔ | | 37018990 | The effects of Chlorella vulgaris on cardiovascular risk factors: A comprehensive review on putative molecular mechanisms |
| Copper | 📋 | ✍ | ⛔ | | 38218941 | Copper homeostasis and cuproptosis in atherosclerosis: metabolism, mechanisms and potential therapeutic strategies |
| Dairy | 📋 | | | | 38726444 | The relationship between fermented and nonfermented dairy products consumption and hypertension among premature coronary artery disease patients: Iran premature coronary artery disease study |
| Dihydroartemisinin | 📋 | | | | 37415610 | Dihydroartemisinin ameliorates cerebral I/R injury in rats via regulating VWF and autophagy-mediated SIRT1/FOXO1 pathway |
| Diosgenin | 📋 | | | | 38643718 | Diosgenin improves post-myocardial infarction cardiac function via HAND2-induced angiogenesis |
| Essential Oils | 📋 | | ⛔ | | 37570643 | Potential Application of the Plant-Derived Essential Oils for Atherosclerosis Treatment: Molecular Mechanisms and Therapeutic Potential |
| Fenugreek | 📋 | ✍ | ⛔ | | 38450419 | Fenugreek extract improves diabetes-induced endothelial dysfunction via the arginase 1 pathway |
| Honey | 📋 | ✍ | ⛔ | | 37458648 | Comparative effectiveness of adding omega-3 and Manuka honey combination to conventional therapy in preventing and treating oxidative stress in pediatric β-thalassemia major - a randomized clinical trial |
| Horny Goat Weed | 📋 | ✍ | ⛔ | | 37237865 | Epimedium Aqueous Extract Ameliorates Cerebral Ischemia/Reperfusion Injury through Inhibiting ROS/NLRP3-Mediated Pyroptosis |
| Isoquercitrin | 📋 | | | | 37391332 | Isoquercitrin Played a Neuroprotective Role in Rats After Cerebral Ischemia/Reperfusion Through Up-Regulating Neuroglobin and Anti-Oxidative Stress |
| L-Leucine | 📋 | ✍ | ⛔ | | 38165500 | Cardioprotective Effects of Leucine Supplementation against Doxorubicin-Induced Cardiotoxicit |
| Morin | 📋 | | | | 38331877 | Morin ameliorates myocardial injury in diabetic rats via modulation of inflammatory pathways |
| Oats | 📋 | | ⛔ | | 37513599 | Oat Beta-Glucan Alone and in Combination with Hydrochlorothiazide Lowers High Blood Pressure in Male but Not Female Spontaneously Hypertensive Rats |
| Oleic Acid | 📋 | | ⛔ | | 37817162 | The mechanism of oleic acid inhibiting platelet activation stimulated by collagen |
| Oolong Tea | 📋 | | ⛔ | | 35600813 | Green and Oolong Tea Extracts With Different Phytochemical Compositions Prevent Hypertension and Modulate the Intestinal Flora in a High-Salt Diet Fed Wistar Rats |
| Pyridoxal-5-Phosphate | 📋 | ✍ | ⛔ | | 37946524 | Upregulation of ATP-Sensitive Potassium Channels as the Potential Mechanism of Cardioprotection and Vasorelaxation Under the Action of Pyridoxal-5-Phosphate in Old Rats |
| Royal Jelly | 📋 | ✍ | ⛔ | | 38657030 | Comparative neuroprotective effects of royal jelly and its unique compound 10-hydroxy-2-decenoic acid on ischemia-induced inflammatory, apoptotic, epigenetic and genotoxic changes in a rat model of ischemic stroke |
| Safranal | 📋 | | | | 38234630 | Safranal acts as a neurorestorative agent in rats with cerebral ischemic stroke via upregulating SIRT1 |
| Soy | 📋 | ✍ | ⛔ | | 38520523 | Associations of soy product intake with all-cause, cardiovascular disease and cancer mortality: Guangzhou Biobank Cohort Study and updated meta-analyses |
| Soy Isoflavones | 📋 | ✍ | ⛔ | | 38454401 | Effect of soy isoflavone supplementation on blood pressure: a meta-analysis of randomized controlled trials |
| Stevia | 📋 | ✍ | ⛔ | | 35588653 | Stevia rebaudiana Bertoni and its secondary metabolites: Their effects on cardiovascular risk factors |
| Ursolic Acid | 📋 | ✍ | ⛔ | | 37834220 | Ursolic Acid Alleviates Neuroinflammation after Intracerebral Hemorrhage by Mediating Microglial Pyroptosis via the NF-κB/NLRP3/GSDMD Pathway |
| Valerian Root | 📋 | ✍ | ⛔ | | 37908890 | CARDIOPROTECTIVE EFFECT OF DICHLOROMETHANE VALERIAN (VALERIANA OFFICINALIS) EXTRACT ON ISCHEMIA-REPERFUSION-INDUCED CARDIAC INJURIES IN RATS |
| Avocado | 📋 | ✍ | ⛔ | | 37525782 | Effect of Avocado Consumption on Risk Factors of Cardiovascular Diseases: A Systematic Review and Meta-Analysis |
| Bay Leaf | 📋 | | ⛔ | | 35549860 | Study of the Antihypertensive Effect of Laurus nobilis in Rats |
| Bilberry | 📋 | ✍ | ⛔ | | 37351191 | A grape seed and bilberry extract reduces blood pressure in individuals at risk of developing type 2 diabetes: the PRECISE study, a double-blind placebo-controlled cross-over intervention study |
| Brazil Nut | 📋 | | ⛔ | | 34156903 | Impact of Brazil Nut ( Bertholletia excelsa, H.B.K.) Supplementation on Body Composition, Blood Pressure, and the Vascular Reactivity of Wistar Rats When Submitted to a Hypersodium Diet |
| Butyrate | 📋 | | ⛔ | | 38486971 | Protective effects of butyrate on cerebral ischaemic injury in animal models: a systematic review and meta-analysis |
| Calcium | 📋 | ✍ | ⛔ | | 38613076 | Association between Daily Dietary Calcium Intake and the Risk of Cardiovascular Disease (CVD) in Postmenopausal Korean Women |
| Eucommia | 📋 | ✍ | ⛔ | | 37889854 | Cardioprotection of Eucommiae Folium: the extract and pharmaceutically active compounds attenuate hyperglycemia, mitochondrial dysfunction, calcium dyshomeostasis, insulin resistance, and oxidative stress in diabetic cardiomyopathy db/db mice |
| Galangal | 📋 | ✍ | ⛔ | | 35566064 | Vasodilatory Effect of Alpinia officinarum Extract in Rat Mesenteric Arteries |
| Geraniin | 📋 | | | | 37375598 | Geraniin Ameliorates Hypertensive Vascular Remodelling in a Diet-Induced Obese Animal Model through Antioxidant and Anti-Inflammatory Effects |
| Glabridin | 📋 | | | | 36232674 | Glabridin, a Bioactive Flavonoid from Licorice, Effectively Inhibits Platelet Activation in Humans and Mice |
| Pomegranate Seed extract | 📋 | | ⛔ | | 35782771 | Pomegranate seed oil protects against tacrolimus-induced toxicity in the heart and kidney by modulation of oxidative stress in rats |
| Tetrahydrocurcumin | 📋 | ✍ | | | 37812853 | Tetrahydrocurcumin ameliorates postinfarction cardiac dysfunction and remodeling by inhibiting oxidative stress and preserving mitochondrial function via SIRT3 signaling pathway |
| Vitamin B Complex | 📋 | | ⛔ | | 37850302 | The effect of B-vitamins on the prevention and treatment of cardiovascular diseases: a systematic review and meta-analysis |
| Vitamin K2 mk-4 | 📋 | ✍ | | | 38727984 | Menaquinone-4 Alleviates Neurological Deficits Associated with Intracerebral Hemorrhage by Preserving Corticospinal Tract in Mice |
| Vitamins | 📋 | | | | 38588735 | Effect modification of diet and vitamins on the association between air pollution particles of different diameters and hypertension: A 12-year longitudinal cohort study in densely populated areas of China |
| Wormwood | 📋 | ✍ | ⛔ | | 37898972 | Mechanism of Artemisia annua L. in the treatment of acute myocardial infarction: network pharmacology, molecular docking and in vivo validation |
| Aloe Vera | 📋 | ✍ | ⛔ | | 34355443 | Potential protective effects of Aloe vera gel on cardiovascular diseases: A mini-review |
| Apple Vinegar | 📋 | ✍ | ⛔ | | 37608660 | The effects of apple cider vinegar on cardiometabolic risk factors: A systematic review and meta-analysis of clinical trials |
| Betulinic Acid | 📋 | | | | 36808036 | Betulinic acid protects against cardiotoxicity of the organophosphorus pesticide chlorpyrifos by suppressing oxidative stress, inflammation, and apoptosis in rats |
| Blackcurrant | 📋 | ✍ | ⛔ | | 35293002 | The antioxidant, anti-inflammatory, and antiplatelet effects of Ribes rubrum L. fruit extract in the diabetic rats |
| Cardamonin | 📋 | | | | 38585526 | Cardamonin mitigates kidney injury by modulating inflammation, oxidative stress, and apoptotic signaling in rats subjected to renal ischemia and reperfusion |
| Celery | 📋 | | ⛔ | | 38505582 | Antihypertensive Property of Celery: A Narrative Review on Current Knowledge |
| Coconut | 📋 | | ⛔ | | 38696690 | Ameliorative Effects of Coconut Water on Hematological and Lipid Profiles of Phenylhydrazine-treated Rats |
| Diallyl Trisulfide | 📋 | | | | 38185348 | Diallyl trisulfide (DATS) protects cardiac cells against advanced glycation end-product-induced apoptosis by enhancing FoxO3A-dependent upregulation of miRNA-210 |
| Eleuthero | 📋 | ✍ | ⛔ | | 38380572 | Integrating serum pharmacochemistry and network pharmacology to explore the molecular mechanisms of Acanthopanax senticosus (Rupr. & Maxim.) Harms on attenuating doxorubicin-induced myocardial injury |
| Fat | 📋 | | | | 38219649 | Dietary fat quality, plasma atherogenic lipoproteins, and atherosclerotic cardiovascular disease: An overview of the rationale for dietary recommendations for fat intake |
| Glucosamine | 📋 | ✍ | ⛔ | | 37422736 | Association Between Glucosamine Use and the Risk of Incident Heart Failure: The UK Biobank Cohort Study and Mendelian Randomization Analysis |
| Grapefruit | 📋 | | ⛔ | | 35694160 | Grapefruit Juice Flavanones Modulate the Expression of Genes Regulating Inflammation, Cell Interactions and Vascular Function in Peripheral Blood Mononuclear Cells of Postmenopausal Women |
| Inulin | 📋 | ✍ | ⛔ | | 37642581 | Inulin Attenuates Blood-Brain Barrier Permeability and Alleviates Behavioral Disorders by Modulating the TLR4/MyD88/NF-κB Pathway in Mice with Chronic Stress |
| Isorhamnetin | 📋 | | | | 36540030 | Novel preventive effect of isorhamnetin on electrical and structural remodeling in atrial fibrillation |
| L-Theanine | 📋 | ✍ | ⛔ | | 38677602 | L-theanine abates oxidative stress and mitochondrial dysfunction in myocardial ischemia-reperfusion injury by positively regulating the antioxidant response |
| Lemon | 📋 | | ⛔ | | 37686881 | Antihypertensive and Vasorelaxant Effects of Citric Acid and Lemon Juice in Spontaneously Hypertensive Rats: In Vivo and Ex Vivo Studies |
| Linalool | 📋 | | ⛔ | | 37916380 | Hepatoprotective effects of linalool against liver ischemia-reperfusion: the role of Nrf2/HO-1/NQO1 and TLR4/RAGE/NFκB pathways |
| Mango | 📋 | | ⛔ | | 38115868 | The effects of mango consumption on vascular health and immune function |
| Minerals | 📋 | | | | 37998340 | Doxorubicin-Induced Cardiac Senescence Is Alleviated Following Treatment with Combined Polyphenols and Micronutrients through Enhancement in Mitophagy |
| Neohesperidin | 📋 | | | | 35677431 | Neohesperidin Protects Angiotensin II-Induced Hypertension and Vascular Remodeling |
| PEA | 📋 | ✍ | ⛔ | | 35469820 | Palmitoylethanolamide ameliorates neuroinflammation via modulating PPAR-α to promote the functional outcome after intracerebral hemorrhage |
| Phloretin | 📋 | | | | 38223667 | Phloretin targets SIRT1 to alleviate oxidative stress, apoptosis, and inflammation in deep venous thrombosis |
| Piperlongumine | 📋 | | | | 37989300 | Relaxant Effects of Piperine and Piperlongumine from Piper longum Linn. Fruits on Porcine Coronary Artery |
| Pistachio | 📋 | ✍ | ⛔ | | 36856595 | Cardioprotective Effect of Pistacia vera L. (Green Pistachio) Hull Extract in Wistar Albino Rats with Doxorubicin-Induced Cardiac Damage |
| Psyllium | 📋 | ✍ | ⛔ | | 32066221 | The effect of psyllium supplementation on blood pressure: a systematic review and meta-analysis of randomized controlled trials |
| Quercitrin | 📋 | | | | 38447360 | Quercitrin improves cardiac remodeling following myocardial infarction by regulating macrophage polarization and metabolic reprogramming |
| Rhubarb | 📋 | | ⛔ | | 38668344 | The Water Extract of Rhubarb Prevents Ischemic Stroke by Regulating Gut Bacteria and Metabolic Pathways |
| Seafood | 📋 | | | | 38161129 | Association of seafood consumption with cardiovascular disease among adults in Qingdao, China |
| Skullcap | 📋 | ✍ | ⛔ | | 37855354 | Network Pharmacology and Molecular Docking Analysis on Mechanisms of Scutellariae Radix in the Treatment of Cerebral Ischemia-reperfusion Injury |
| St. Johns Wort | 📋 | ✍ | ⛔ | | 36141386 | Hypericum perforatum and Its Potential Antiplatelet Effect |
| Syringic Acid | 📋 | | | | 37604776 | Syringic acid suppresses ferroptosis of skeletal muscle cells to alleviate lower limb ischemia/reperfusion injury in mice via the HMGB1 pathway |
| Tea Polyphenols | 📋 | | | | 38063114 | Protective mechanisms of tea polyphenols regulating the PI3K/Akt pathway on early brain injury after subarachnoid hemorrhage in rats |
| Astragalin | 📋 | | | | 33165140 | Astragalin Retards Atherosclerosis by Promoting Cholesterol Efflux and Inhibiting the Inflammatory Response via Upregulating ABCA1 and ABCG1 Expression in Macrophages |
| BCAA | 📋 | ✍ | ⛔ | | 36501095 | Oral Administration of Branched-Chain Amino Acids Attenuates Atherosclerosis by Inhibiting the Inflammatory Response and Regulating the Gut Microbiota in ApoE-Deficient Mice |
| Bitter Orange | 📋 | ✍ | ⛔ | | 38343915 | Comparative Activities of Three Compounds from Citrus aurantium L. var. amara Engl. to Improve Oxidized Low-Density Lipoprotein-Induced Lipid Deposition |
| Black Pepper | 📋 | ✍ | ⛔ | | 37299525 | Combination of Taurine and Black Pepper Extract as a Treatment for Cardiovascular and Coronary Artery Diseases |
| Blackberry | 📋 | | ⛔ | | 36435288 | Berry consumption mitigates the hypertensive effects of a high-fat, high-sucrose diet via attenuation of renal and aortic AT1R expression resulting in improved endothelium-derived NO bioavailability |
| Boric Acid | 📋 | ✍ | ⛔ | | 38700634 | Concentration-Dependent Effects of Boric Acid on Osteogenic Differentiation of Vascular Smooth Muscle Cells |
| Carrot | 📋 | | ⛔ | | 33918417 | Carrot Supplementation Improves Blood Pressure and Reduces Aortic Root Lesions in an Atherosclerosis-Prone Genetic Mouse Model |
| Chamomile | 📋 | ✍ | ⛔ | | 38226236 | A pharmacological and toxicological biochemical study of cardiovascular regulatory effects of hibiscus, corn silk, marjoram, and chamomile |
| Cyanidin | 📋 | ✍ | | | 38349396 | Cyanidin prevents cardiomyocyte apoptosis in mice after myocardial infarction |
| D-Ribose | 📋 | ✍ | ⛔ | | 35644694 | Effects of Ubiquinol and/or D-ribose in Patients With Heart Failure With Preserved Ejection Fraction |
| Echinacoside | 📋 | | | | 38125366 | Echinacoside ameliorates doxorubicin‑induced cardiac injury by regulating GPX4 inhibition‑induced ferroptosis |
| Elderberry | 📋 | ✍ | ⛔ | | 37457144 | Elderberry extract improves molecular markers of endothelial dysfunction linked to atherosclerosis |
| Eucalyptol | 📋 | | | | 37886137 | Effect of eucalyptol on matrix metalloproteinase-9 and its tissue inhibitor in hypertensive rats |
| Fig | 📋 | | ⛔ | | 34213002 | Protective effects of Ficus carica seed oil on ischemia and reperfusion injury in a rat model of acute mesenteric ischemia |
| Glycyrrhetinic Acid | 📋 | | | | 36070662 | Natural compound glycyrrhetinic acid protects against doxorubicin-induced cardiotoxicity by activating the Nrf2/HO-1 signaling pathway |
| Grapefruit extract | 📋 | ✍ | ⛔ | | 37283121 | Flavonoids from Citrus paradise cv. Changshan-huyou exerts protective effect on ischemia-induced cerebral injury in mice via inhibiting RhoA-ROCK2 signaling pathway |
| Graviola | 📋 | ✍ | ⛔ | | 34018384 | Compensatory depression of arterial pressure and reversal of ECG abnormalities by Annona muricata and Curcuma longa in hypertensive Wistar rats |
| Haritaki | 📋 | ✍ | ⛔ | | 36558549 | Chebulic Acid Prevents Hypoxia Insult via Nrf2/ARE Pathway in Ischemic Stroke |
| Holy Basil | 📋 | ✍ | ⛔ | | 37763282 | Ocimum sanctum Alters the Lipid Landscape of the Brain Cortex and Plasma to Ameliorate the Effect of Photothrombotic Stroke in a Mouse Model |
| Isoflavones | 📋 | ✍ | ⛔ | | 38399451 | Isoflavones Effects on Vascular and Endothelial Outcomes: How Is the Gut Microbiota Involved? |
| Krill Oil | 📋 | ✍ | ⛔ | | 38139268 | Antarctic Krill Oil from Euphausia superba Ameliorates Carrageenan-Induced Thrombosis in a Mouse Model |
| Lactobacillus plantarum | 📋 | | ⛔ | | 38229862 | Regulatory Effect of Spray-Dried Lactiplantibacillus plantarum K79 on the Activation of Vasodilatory Factors and Inflammatory Responses |
| Licochalcones | 📋 | | | | 38078919 | Licochalcone A alleviates ferroptosis in doxorubicin-induced cardiotoxicity via the PI3K/AKT/MDM2/p53 pathway |
| Myrtle | 📋 | ✍ | ⛔ | | 34388525 | Effect of supplementation of Rhodomyrtus tomentosa fruit juice in preventing hypercholesterolemia and atherosclerosis development in rats fed with high fat high cholesterol diet |
| Parthenolide | 📋 | | | | 38100883 | MCL attenuates atherosclerosis by suppressing macrophage ferroptosis via targeting KEAP1/NRF2 interaction |
| Perilla | 📋 | ✍ | | | 38053825 | Purple perilla frutescens extracts containing α-asarone inhibit inflammatory atheroma formation and promote hepatic HDL cholesterol uptake in dyslipidemic apoE-deficient mice |
| PQQ | 📋 | ✍ | ⛔ | | 36238573 | Pyrroloquinoline quinone modulates YAP-related anti-ferroptotic activity to protect against myocardial hypertrophy |
| Proanthocyanidins | 📋 | | | | 37719964 | Proanthocyanidin Alleviates Liver Ischemia/Reperfusion Injury by Suppressing Autophagy and Apoptosis via the PPARα/PGC1α Signaling Pathway |
| Progesterone | 📋 | ✍ | ⛔ | | 38140038 | Neuroprotective-Neurorestorative Effects Induced by Progesterone on Global Cerebral Ischemia: A Narrative Review |
| Pumpkin Seed Oil | 📋 | ✍ | ⛔ | | 31445363 | The effects of pumpkin seed oil supplementation on arterial hemodynamics, stiffness and cardiac autonomic function in postmenopausal women |
| Sesame | 📋 | ✍ | ⛔ | | 37940577 | Effects of Combining Docosahexaenoic Acid and Eicosapentaenoic Acid with Sesame Lignan on Vascular Endothelial Function |
| Sesamol | 📋 | | | | 38350822 | Protective Effects of Sesamol on Renal Ischemia-Reperfusion Injury Via Regulation of Nuclear Factor Erythroid 2-Related Factor 2 Pathway |
| Shiitake Mushrooms | 📋 | ✍ | ⛔ | | 38257149 | Hepatoprotection of a Standardized Extract of Cultured Lentinula edodes Mycelia against Liver Injury Induced by Ischemia-Reperfusion and Partial Hepatectomy |
| Sirtuin Activators | 📋 | | | | 38038821 | Natural Sirtuin1 Activators and Atherosclerosis: an Overview |
| Arachidonic Acid | 📋 | ✍ | ⛔ | | 38336692 | Protective role of arachidonic acid against diabetic myocardial ischemic injury: a translational study of pigs, rats, and humans |
| Artichoke | 📋 | ✍ | ⛔ | | 35949557 | Anti-hypertensive Effects of Artichoke Supplementation in Adults: A Systematic Review and Dose-response Meta-analysis of Randomized Controlled Trials |
| Avocado Oil | 📋 | | ⛔ | | 34832999 | Avocado Oil Prevents Kidney Injury and Normalizes Renal Vasodilation after Adrenergic Stimulation in Hypertensive Rats: Probable Role of Improvement in Mitochondrial Dysfunction and Oxidative Stress |
| Beta-Alanine | 📋 | ✍ | ⛔ | | 36038575 | Multi-target action of β-alanine protects cerebellar tissue from ischemic damage |
| Bitter Melon | 📋 | ✍ | ⛔ | | 37869921 | Investigation of the effect of addition of Momordica charantia to glibenclamide on amelioration of endothelial dysfunction in diabetic rats by activating Takeda G protein-coupled receptor 5 |
| Bromelain | 📋 | ✍ | ⛔ | | 36670934 | Bromelain Ameliorates Atherosclerosis by Activating the TFEB-Mediated Autophagy and Antioxidant Pathways |
| Cat's Claw | 📋 | ✍ | ⛔ | | 35260150 | GlucoMedix®, an extract of Stevia rebaudiana and Uncaria tomentosa, reduces hyperglycemia, hyperlipidemia, and hypertension in rat models without toxicity: a treatment for metabolic syndrome |
| Chia Seeds | 📋 | | ⛔ | | 38316807 | Chia seeds ameliorate cardiac disease risk factors via alleviating oxidative stress and inflammation in rats fed high-fat diet |
| Chromium | 📋 | ✍ | ⛔ | | 37809394 | The role of chromium supplementation in cardiovascular risk factors: A comprehensive reviews of putative molecular mechanisms |
| Cinnamic Acid | 📋 | | | | 37453198 | Cinnamic acid mitigates left ventricular hypertrophy and heart failure in part through modulating FTO-dependent N6-methyladenosine RNA modification in cardiomyocytes |
| Cornus | 📋 | | | | 37813285 | Loganin protects against myocardial ischemia-reperfusion injury by modulating oxidative stress and cellular apoptosis via activation of JAK2/STAT3 signaling |
| Cryptotanshinone | 📋 | | | | 37435898 | Cryptotanshinone ameliorates hemorrhagic shock-induced liver injury via activating the Nrf2 signaling pathway |
| DIM | 📋 | ✍ | ⛔ | | 38327044 | Protective effect of diindolylmethane-enriched dietary cabbage against doxorubicin-induced cardiotoxicity in mice |
| Eucalyptus | 📋 | ✍ | ⛔ | | 34685597 | 1,8-Cineole Affects Agonists-Induced Platelet Activation, Thrombus Formation and Haemostasis |
| Forskolin | 📋 | ✍ | ⛔ | | 34188435 | Forskolin eye drops improve retinal damage from ischemia/reperfusion |
| Fufang Danshen | 📋 | | | | 34107328 | Chemical composition, quality control, pharmacokinetics, pharmacological properties and clinical applications of Fufang Danshen Tablet: A systematic review |
| Guava | 📋 | | ⛔ | | 36271572 | Effects of Psidium guajava L. leaves extract on blood pressure control and IL-10 production in salt-dependent hypertensive rats |
| Horse Chestnut | 📋 | ✍ | ⛔ | | 34206691 | Potential Activity Mechanisms of Aesculus hippocastanum Bark: Antioxidant Effects in Chemical and Biological In Vitro Models |
| Jasmine | 📋 | | ⛔ | | 36861238 | Evaluation of Anti-clotting and thrombolytic potential of the aqueous-methanolic extract of Jasminum sambac |
| Knotweed | 📋 | ✍ | ⛔ | | 35669500 | Investigation of the Potential Key Genes and the Multitarget Mechanisms of Polygonum cuspidatum against Heart Failure Based on Network Pharmacology and Experimental Validation |
| L-Histidine | 📋 | ✍ | ⛔ | | 36404849 | Protective effect of acetylcysteine, histidine, and their combination against diabetes vascular complications in type-2 diabetic rats via reducing NF-kβ pathway signaling |
| Limonin | 📋 | | | | 37290669 | Limonin ameliorates cardiovascular dysfunction and remodeling in hypertensive rats |
| Lingonberry | 📋 | | ⛔ | | 35930435 | On the effect of flavonoids and dietary fibre in lingonberries on atherosclerotic plaques, lipid profiles and gut microbiota composition in Apoe-/- mice |
| Lupeol | 📋 | | | | 37976692 | Lupeol alleviates autoimmune myocarditis by suppressing macrophage pyroptosis and polarization via PPARα/LACC1/NF-κB signaling pathway |
| Maitake Mushrooms | 📋 | | ⛔ | | 31139649 | Structural Elucidation and Immune-Enhancing Effects of Novel Polysaccharide from Grifola frondosa |
| Olive | 📋 | ✍ | ⛔ | | 38704428 | Olive oil consumption is associated with lower cancer, cardiovascular and all-cause mortality among Italian adults: prospective results from the Moli-sani Study and analysis of potential biological mechanisms |
| Omega-6 Fatty Acids | 📋 | ✍ | ⛔ | | 37971997 | Association between the intake of dietary n3 and n6 fatty acids and stroke in US adults: A cross-sectional study of NHANES 2007-2018 |
| Patchouli | 📋 | ✍ | ⛔ | | 37177974 | Patchouli alcohol against renal fibrosis of spontaneously hypertensive rats via Ras/Raf-1/ERK1/2 signalling pathway |
| Plum | 📋 | | ⛔ | | 35557202 | Fruit-juice Concentrate of Asian Plum Attenuates Vascular Remodeling Associated with Hypertension |
| Pomelo | 📋 | | ⛔ | | 35571242 | Pomelo Peel Essential Oil Ameliorates Cerebral Ischemia-Reperfusion Injury through Regulating Redox Homeostasis in Rats and SH-SY5Y Cells |
| Prebiotics | 📋 | ✍ | ⛔ | | 38411391 | Advancing lifelong precision medicine for cardiovascular diseases through gut microbiota modulation |
| Pregnenolone | 📋 | ✍ | ⛔ | | 37242448 | Pregnenolone Inhibits Doxorubicin-Induced Cardiac Oxidative Stress, Inflammation, and Apoptosis-Role of Matrix Metalloproteinase 2 and NADPH Oxidase 1 |
| Pu-erh Tea | 📋 | ✍ | ⛔ | | 33598200 | Hypolipidemic, anti-inflammatory, and anti-atherosclerotic effects of tea before and after microbial fermentation |
| Rehmannia | 📋 | ✍ | ⛔ | | 37556607 | Rehmannia Glutinosa Polysaccharide Regulates Bone Marrow Microenvironment via HIF-1α/NF-κB Signaling Pathway in Aplastic Anemia Mice |
| Rice | 📋 | | ⛔ | | 35387354 | Taxifolin as a Major Bioactive Compound in the Vasorelaxant Effect of Different Pigmented Rice Bran Extracts |
| Sage | 📋 | ✍ | ⛔ | | 38472741 | Sage (Salvia officinalis) alleviates trazadone induced rat cardiotoxicity mediated via modulation of autophagy and oxidative stress |
| Salt | 📋 | | ⛔ | | 35788204 | Role of no table salt on hypertension and stroke based on large sample size from National Health and Nutrition Examination Survey database |
| Star Fuit | 📋 | | ⛔ | | 31733577 | Effect of an aqueous extract of Averrhoa carambola L. on endothelial function in rats with ventricular remodelling |
| Stigmasterol | 📋 | | | | 36871980 | Stigmasterol protects human brain microvessel endothelial cells against ischemia-reperfusion injury through suppressing EPHA2 phosphorylation |
| Sweet Potato | 📋 | | ⛔ | | 35712860 | The Protective Effect of Sweet Potato Root Tuber on Chemotherapy-Induced Thrombocytopenia |
| Theobromine | 📋 | ✍ | ⛔ | | 25869509 | Effects of high flavanol dark chocolate on cardiovascular function and platelet aggregation |
| Thyme | 📋 | ✍ | ⛔ | | 35228189 | Cardioprotective potential of Thymus linearis Benth |
| Yogurt | 📋 | | ⛔ | | 38053820 | Association of milk and dairy product consumption with the incidence of cardio-cerebrovascular disease incidence in middle-aged and older Korean adults: a 16-year follow-up of the Korean Genome and Epidemiology Study |
| 5-HTP | 📋 | ✍ | ⛔ | | 38462693 | 5-Hydroxytryptophan acts as a gap junction inhibitor to limit the spread of chemotherapy-induced cardiomyocyte injury and mitochondrial dysfunction |
| Alpha GPC | 📋 | ✍ | ⛔ | | 37723613 | Long-term intake of α-glycerophosphocholine (GPC) suppresses microglial inflammation and blood-brain barrier (BBB) disruption and promotes neurogenesis in senescence-accelerated mice prone 8 (SAMP8) |
| Anthocyanidins | 📋 | | | | 37090778 | Association between dietary intake of anthocyanidins and heart failure among American adults: NHANES (2007-2010 and 2017-2018) |
| Ashitaba | 📋 | ✍ | ⛔ | | 37862040 | Supplementation with Ashitaba ( Angelica keiskei) Yellow Stem Exudate Prevents Aging-Induced Thrombotic Tendencies and Systemic Inflammation Without Affecting Body Weight Gain in Mice |
| Atractylodes | 📋 | ✍ | ⛔ | | 38178130 | Combination of Atractylenolide I, Atractylenolide III, and Paeoniflorin promotes angiogenesis and improves neurological recovery in a mouse model of ischemic Stroke |
| Balloon Flower | 📋 | ✍ | ⛔ | | 38682702 | Platycodin D Ameliorates Type 2 Diabetes-Induced Myocardial Injury by Activating the AMPK Signaling Pathway |
| Bergamot Essential Oil | 📋 | ✍ | ⛔ | | 30847114 | Efficacy of bergamot: From anti-inflammatory and anti-oxidative mechanisms to clinical applications as preventive agent for cardiovascular morbidity, skin diseases, and mood alterations |
| Beta-Cryptoxanthin | 📋 | | | | 32362203 | β-cryptoxanthin alleviates myocardial ischaemia/reperfusion injury by inhibiting NF-κB-mediated inflammatory signalling in rats |
| Beta-Glucan | 📋 | ✍ | ⛔ | | 37513599 | Oat Beta-Glucan Alone and in Combination with Hydrochlorothiazide Lowers High Blood Pressure in Male but Not Female Spontaneously Hypertensive Rats |
| Boron | 📋 | ✍ | ⛔ | | 34825958 | Plasma boron concentrations in the general population: a cross-sectional analysis of cardio-metabolic and dietary correlates |
| Cabbage | 📋 | | ⛔ | | 38327044 | Protective effect of diindolylmethane-enriched dietary cabbage against doxorubicin-induced cardiotoxicity in mice |
| Citrus Fruits | 📋 | | ⛔ | | 35499960 | Associations between fruit consumption and home blood pressure in a randomly selected sample of the general Swedish population |
| Conjugated Linoleic Acid | 📋 | ✍ | ⛔ | | 36614314 | Conjugated Linoleic Acids Have Anti-Inflammatory Effects in Cultured Endothelial Cells |
| Coumaric acid | 📋 | | | | 38439645 | Cardioprotective effects of p-coumaric acid on tachycardia, inflammation, ion pump dysfunction, and electrolyte imbalance in isoproterenol-induced experimental myocardial infarction |
| Cucumber | 📋 | | ⛔ | | 38162466 | Cucumber ( Cucumis sativus L.) Fruit and Combination with Losartan Attenuate the Elevation of Blood Pressure in Hypertensive Rats Induced by Angiotensin II |
| D-Limonene | 📋 | ✍ | ⛔ | | 37322623 | L-limonene reduces aortic artery atherosclerosis by inhibiting oxidative stress/inflammatory responses in diabetic rats fed high-fat diet |
| Docosapentaenoic Acid | 📋 | ✍ | | | 38117698 | Association between dietary omega-3 intake and coronary heart disease among American adults: The NHANES, 1999-2018 |
| Echinacea | 📋 | ✍ | ⛔ | | 28061036 | Antioxidant, Antidiabetic, and Antihypertensive Properties of Echinacea Purpurea Flower Extract and Caffeic Acid Derivatives Using In Vitro Models |
| Egg | 📋 | | ⛔ | | 36027152 | FUNCTIONAL FOOD ENRICHED IN N-3 POLYUNSATURATED FATTY ACIDS, SELENIUM, LUTEIN AND VITAMIN E ENHANCES MICROVASCULAR ENDOTHELIAL FUNCTION OF COMPETITIVE ATHLETES |
| Equol | 📋 | ✍ | ⛔ | | 38399451 | Isoflavones Effects on Vascular and Endothelial Outcomes: How Is the Gut Microbiota Involved? |
| Essential Amino Acids | 📋 | ✍ | ⛔ | | 37397466 | A balanced formula of essential amino acids promotes brain mitochondrial biogenesis and protects neurons from ischemic insult |
| Flavones | 📋 | | | | 38630898 | The association between flavonoids intake and hypertension in U.S. adults: A cross-sectional study from The National Health and Nutrition Examination Survey |
| GABA | 📋 | ✍ | ⛔ | | 38487926 | Prophylactic Supplementation with Lactobacillus Reuteri or Its Metabolite GABA Protects Against Acute Ischemic Cardiac Injury |
| Gamma-Linolenic Acid | 📋 | ✍ | ⛔ | | 37608640 | Efficacy of γ-linolenic acid, Vitis vinifera extract, and acetyl-L-carnitine combination therapy for improving arterial stiffness in Korean adults: Real-world evidence |
| Ganoderic Acid | 📋 | | | | 38417185 | Ganoderic acids alleviate atherosclerosis by inhibiting macrophage M1 polarization via TLR4/MyD88/NF-κB signaling pathway |
| Garlic Oil | 📋 | | ⛔ | | 36364887 | Perinatal Garlic Oil Supplementation Averts Rat Offspring Hypertension Programmed by Maternal Chronic Kidney Disease |
| Hazelnut | 📋 | | ⛔ | | 32742827 | A Pilot Study on the Effects of Nut Consumption on Cardiovascular Biomarkers |
| Indian Mulberry | 📋 | ✍ | ⛔ | | 36866542 | The Investigation of the Molecular Mechanism of Morinda officinalis How in the Treatment of Heart Failure |
| L-Lysine | 📋 | ✍ | ⛔ | | 38639736 | Lysine and salt-sensitive hypertension |
| Laminaria | 📋 | ✍ | ⛔ | | 37067393 | Inhibition of Ca2+-calpain signaling is a new mechanism using Laminaria japonica polysaccharide to prevent macrophage foam cell formation and atherosclerosis |
| Lemongrass | 📋 | ✍ | ⛔ | | 36290288 | Exploring the Anti-Hypertensive Potential of Lemongrass-A Comprehensive Review |
| Liquiritigenin | 📋 | | | | 35747908 | Liquiritigenin protects against myocardial ischemic by inhibiting oxidative stress, apoptosis, and L-type Ca 2+ channels |
| Long Pepper | 📋 | | ⛔ | | 36435434 | Effects of dichloromethane extraction from Piper nigrum L. and P. longum L. on the expression of autophagy-related proteins in ischemic stroke |
| Loquat | 📋 | ✍ | ⛔ | | 34878451 | A functional polysaccharide from Eriobotrya japonica relieves myocardial ischemia injury via anti-oxidative and anti-inflammatory effects |
| Magnolia | 📋 | ✍ | ⛔ | | 35308213 | Vasorelaxant Activities and its Underlying Mechanisms of Magnolia Volatile Oil on Rat Thoracic Aorta Based on Network Pharmacology |
| Mango Leaf | 📋 | | ⛔ | | 29937737 | Mangifera indica L. Leaf Extract in Combination With Luteolin or Quercetin Enhances VO 2 peak and Peak Power Output, and Preserves Skeletal Muscle Function During Ischemia-Reperfusion in Humans |
| Marigold | 📋 | ✍ | ⛔ | | 33683221 | The effect of sucralfate-containing ointment on quality of life in people with symptoms associated with haemorrhoidal disease and its complications: the results of the EMOCARE survey |
| Marjoram | 📋 | | ⛔ | | 38226236 | A pharmacological and toxicological biochemical study of cardiovascular regulatory effects of hibiscus, corn silk, marjoram, and chamomile |
| Milk | 📋 | | ⛔ | | 35268066 | Cow's Milk Intake and Risk of Coronary Heart Disease in Korean Postmenopausal Women |
| Motherwort | 📋 | ✍ | ⛔ | | 38732560 | Characterizations of White Mulberry, Sea-Buckthorn, Garlic, Lily of the Valley, Motherwort, and Hawthorn as Potential Candidates for Managing Cardiovascular Disease-In Vitro and Ex Vivo Animal Studies |
| Nootkatone | 📋 | | | | 36001774 | Nootkatone Ameliorates Doxorubicin Induced Myocardial Injury through Modulation of NF-κB Signals and Oxidative Stress |
| Oleanolic Acid | 📋 | | | | 35346820 | Pentacyclic triterpene oleanolic acid protects against cardiac aging through regulation of mitophagy and mitochondrial integrity |
| Phytosterols | 📋 | | | | 38722432 | Unveiling the molecular mechanisms: dietary phytosterols as guardians against cardiovascular diseases |
| Rapeseed Oil | 📋 | ✍ | | | 35596008 | The effects of sesame, canola, and sesame-canola oils on cardiometabolic markers in patients with type 2 diabetes: a triple-blind three-way randomized crossover clinical trial |
| Rosemary | 📋 | ✍ | ⛔ | | 37535015 | Medicinal plant rosemary relaxes blood vessels by activating vascular smooth muscle KCNQ channels |
| Rosemary Essential Oil | 📋 | ✍ | ⛔ | | 37141519 | [Impact of essential oil vapors inhalation on blood pressure in patients with hypertension] |
| SAMe | 📋 | ✍ | ⛔ | | 38489960 | Plasma metabolomics identifies S-adenosylmethionine as a biomarker and potential therapeutic target for vascular aging in older adult males |
| Scutellarein | 📋 | | | | 38516760 | Food therapy of scutellarein ameliorates pirarubicin‑induced cardiotoxicity in rats by inhibiting apoptosis and ferroptosis through regulation of NOX2‑induced oxidative stress |
| Serrapeptase | 📋 | ✍ | ⛔ | | 36975512 | Serratiopeptidase Attenuates Lipopolysaccharide-Induced Vascular Inflammation by Inhibiting the Expression of Monocyte Chemoattractant Protein-1 |
| Soybean Oil | 📋 | | ⛔ | | 37461334 | Effect of lard plus soybean oil on blood pressure and other cardiometabolic risk factors in healthy subjects: a randomized controlled-feeding trial |
| Spices | 📋 | | | | 37236043 | Potential benefits of spicy food consumption on cardiovascular outcomes in patients with diabetes: A cohort study of the China Kadoorie Biobank |
| Vitamin B8 | 📋 | ✍ | ⛔ | | 35268093 | Beneficial In Vitro Effects of a Low Myo-Inositol Dose in the Regulation of Vascular Resistance and Protein Peroxidation under Inflammatory Conditions |
| Watermelon | 📋 | | ⛔ | | 37369281 | Watermelon consumption decreases risk factors of cardiovascular diseases: A systematic review and meta-analysis of randomized controlled trials |
| Anise | 📋 | ✍ | ⛔ | | 37727035 | Protective effects of anise in prevention of cerebral ischemia reperfusion injury in rats |
| Apricot | 📋 | | ⛔ | | 35702770 | Antihypertensive Activity of Prunus armeniaca in Hypertensive Rats |
| Arctiin | 📋 | | | | 32135123 | Arctiin protects rat heart against ischemia/reperfusion injury via a mechanism involving reduction of necroptosis |
| Asafoetida | 📋 | ✍ | ⛔ | | 38520834 | Kellerin alleviates cerebral ischemic injury by inhibiting ferroptosis via targeting Akt-mediated transcriptional activation of Nrf2 |
| Banana | 📋 | | ⛔ | | 37655002 | Antioxidant and anti-atherosclerotic potential of Banana ( Musa spp): A review of biological mechanisms for prevention and protection against atherosclerosis |
| Barley | 📋 | ✍ | ⛔ | | 37836470 | Whole-Grain Highland Barley Attenuates Atherosclerosis Associated with NLRP3 Inflammasome Pathway and Gut Microbiota in ApoE-/- Mice |
| Basil | 📋 | ✍ | ⛔ | | 37064472 | Phytochemical characterization, antioxidant activity and antihypertensive evaluation of Ocimum basilicum L. in l-NAME induced hypertensive rats and its correlation analysis |
| Basil Essential Oil | 📋 | ✍ | ⛔ | | 37141519 | [Impact of essential oil vapors inhalation on blood pressure in patients with hypertension] |
| Beta-Lapachone | 📋 | | | | 35738116 | β-Lapachone, an NQO1 activator, alleviates diabetic cardiomyopathy by regulating antioxidant ability and mitochondrial function |
| Bile Salts | 📋 | | | | 38180064 | Bile salt signaling and bile salt-based therapies in cardiometabolic disease |
| Capsanthin | 📋 | | | | 35892680 | Capsanthin Inhibits Atherosclerotic Plaque Formation and Vascular Inflammation in ApoE -/- Mice |
| Caraway | 📋 | | ⛔ | | 36284942 | Effect of Caraway Seed Extract on the Blood Biochemistry and Antioxidant Capacity among the Hyperoxidative Stress-Induced Rats |
| Carnosol | 📋 | | | | 36775042 | Carnosol inhibits cerebral ischemia-reperfusion injury by promoting AMPK activation |
| Casein Protein | 📋 | ✍ | ⛔ | | 36235859 | Effect of Casein Hydrolysate on Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis of Randomized Controlled Trials |
| Chamomile Essential Oil | 📋 | ✍ | ⛔ | | 29615934 | Chamazulene Attenuates ROS Levels in Bovine Aortic Endothelial Cells Exposed to High Glucose Concentrations and Hydrogen Peroxide |
| Chicory | 📋 | ✍ | ⛔ | | 36774178 | Brussels Chicory Stabilizes Unstable Atherosclerotic Plaques and Reshapes the Gut Microbiota in Apoe-/- Mice |
| Clove | 📋 | | ⛔ | | 15934019 | Antioxidant activity of DHC-1, an herbal formulation, in experimentally-induced cardiac and renal damage |
| Collagen | 📋 | ✍ | | | 38140281 | Effects of Long-Term Administration of Bovine Bone Gelatin Peptides on Myocardial Hypertrophy in Spontaneously Hypertensive Rats |
| Corn Silk | 📋 | ✍ | ⛔ | | 38226236 | A pharmacological and toxicological biochemical study of cardiovascular regulatory effects of hibiscus, corn silk, marjoram, and chamomile |
| Costus | 📋 | ✍ | ⛔ | | 35710877 | Costunolide alleviates atherosclerosis in high-fat diet-fed ApoE -/- mice through covalently binding to IKKβ and inhibiting NF-κB-mediated inflammation |
| Creatine | 📋 | ✍ | ⛔ | | 34684484 | Cardiac Oxidative Stress and the Therapeutic Approaches to the Intake of Antioxidant Supplements and Physical Activity |
| Delphinidin | 📋 | | | | 35130117 | Delphinidin-3- O-glucoside, an active compound of Hibiscus sabdariffa calyces, inhibits oxidative stress and inflammation in rabbits with atherosclerosis |
| Diallyl Disulfide | 📋 | | | | 34646139 | The Potential Benefits of Using Garlic Oil and Its Active Constituent, Dially Disulphide, in Combination With Carvedilol in Ameliorating Isoprenaline-Induced Cardiac Damage in Rats |
| Dragon Fruit | 📋 | | ⛔ | | 35265960 | Betalain-rich dragon fruit (pitaya) consumption improves vascular function in adult men and women: a double-blind, randomized controlled crossover trial |
| Eggplant | 📋 | | ⛔ | | 36985807 | Evaluation of the Antihypertensive Activity of Eggplant Acetylcholine and γ-Aminobutyric Acid in Spontaneously Hypertensive Rats |
| Essential Fatty Acids | 📋 | ✍ | | | 34680583 | Essential Fatty Acids as Biomedicines in Cardiac Health |
| Fish Collagen | 📋 | ✍ | ⛔ | | 36090717 | Venous leg ulcers treated with fish collagen gel in a 12-week randomized single-centre study |
| Gardenia | 📋 | | ⛔ | | 36388796 | Investigation of the hemostatic mechanism of Gardeniae fructus Praeparatus based on pharmacological evaluation and network pharmacology |
| Ginkgolic Acid | 📋 | | | | 29524504 | Pharmacological inhibition of SUMO-1 with ginkgolic acid alleviates cardiac fibrosis induced by myocardial infarction in mice |
| Glycine | 📋 | ✍ | ⛔ | | 37805752 | [Effects and mechanism of glycine on rat cardiomyocytes pretreated with serum from burned rats] |
| Goat Milk | 📋 | | ⛔ | | 37830350 | Fermented Goat's Milk Contributes to the Recovery of Iron Deficiency Anemia via Modulation of the Gut Microbiome |
| Guggulsterone | 📋 | | | | 37230158 | Novel synergistic mechanism of 11-keto-β-boswellic acid and Z-Guggulsterone on ischemic stroke revealed by single-cell transcriptomics |
| Helichrysum | 📋 | | ⛔ | | 35739989 | The Potential Role of Everlasting Flower ( Helichrysum stoechas Moench) as an Antihypertensive Agent: Vasorelaxant Effects in the Rat Aorta |
| Hemp Oil | 📋 | ✍ | ⛔ | | 34037390 | Cannabis Seed Oil Alleviates Experimental Atherosclerosis by Ameliorating Vascular Inflammation in Apolipoprotein-E-Deficient Mice |
| Hyaluronic Acid | 📋 | ✍ | ⛔ | | 32213158 | Hyaluronic Acid and Regenerative Medicine: New Insights Into the Stroke Therapy |
| Hypericin | 📋 | | | | 38547517 | Hypericin alleviates Chronic Kidney Disease induced Left Ventricular Hypertrophy via regulation of FGF23-FGFR4 signaling pathway |
| Jujube | 📋 | | ⛔ | | 35783519 | Jujuboside A Ameliorates Myocardial Apoptosis and Inflammation in Rats with Coronary Heart Disease by Inhibiting PPAR- α Signaling Pathway |
| L-Tryptophan | 📋 | ✍ | ⛔ | | 34576067 | Tryptophan: From Diet to Cardiovascular Diseases |
| Lemon Verbena | 📋 | | ⛔ | | 33810049 | A Randomized, Double-Blind, Placebo-Controlled Trial to Determine the Effectiveness of a Polyphenolic Extract ( Hibiscus sabdariffa and Lippia citriodora) for Reducing Blood Pressure in Prehypertensive and Type 1 Hypertensive Subjects |
| Lime Essential Oil | 📋 | ✍ | ⛔ | | 34815773 | Cold-pressed oil from Citrus aurantifolia inhibits the proliferation of vascular smooth muscle cells via regulation of PI3K/MAPK signaling pathways |
| Lychee | 📋 | | ⛔ | | 33470120 | Polyphenol-Rich Extract from Litchi chinensis Seeds Alleviates Hypertension-Induced Renal Damage in Rats |
| Maca Root | 📋 | ✍ | ⛔ | | 34765511 | Lepidium meyenii (maca) and soy isoflavones reduce cardiac stunning of ischemia-reperfusion in rats by mitochondrial mechanisms |
| Madecassoside | 📋 | | | | 32949562 | Blood-Brain Barrier Permeability of Asiaticoside, Madecassoside and Asiatic Acid in Porcine Brain Endothelial Cell Model |
| Millet | 📋 | | | | 38419846 | Does millet consumption contribute to raising blood hemoglobin levels compared to regular refined staples?: a systematic review and meta-analysis |
| MSM | 📋 | ✍ | ⛔ | | 30038844 | Methylsulfonylmethane decreases inflammatory response to tumor necrosis factor-α in cardiac cells |
| Myrrh Essential Oil | 📋 | | ⛔ | | 36826023 | Myrrh Essential Oil Mitigates Renal Ischemia/Reperfusion-Induced Injury |
| Nimbolide | 📋 | | | | 35199915 | Nimbolide retards T cell lymphoma progression by altering apoptosis, glucose metabolism, pH regulation, and ROS homeostasis |
| Oak Bark | 📋 | ✍ | ⛔ | | 22105311 | Cardioprotective and hepatoprotective effects of ellagitannins from European oak bark (Quercus petraea L.) extract in rats |
| Papain | 📋 | ✍ | ⛔ | | 38069092 | Unveiling the Potent Fibrino(geno)lytic, Anticoagulant, and Antithrombotic Effects of Papain, a Cysteine Protease from Carica papaya Latex Using κ-Carrageenan Rat Tail Thrombosis Model |
| Pear | 📋 | | ⛔ | | 35499960 | Associations between fruit consumption and home blood pressure in a randomly selected sample of the general Swedish population |
| Pecan | 📋 | | ⛔ | | 36822079 | Pecan-enriched diet improves cholesterol profiles and enhances postprandial microvascular reactivity in older adults |
| Phosphatidylcholine | 📋 | ✍ | ⛔ | | 34990309 | Effect of soya phosphatidylcholine and possible underlying mechanism on ischemia/reperfusion injury in isolated perfused rat heart: an experimental and computational study |
| Phosphatidylserine | 📋 | ✍ | ⛔ | | 33922385 | Phosphatidylserine Supplementation as a Novel Strategy for Reducing Myocardial Infarct Size and Preventing Adverse Left Ventricular Remodeling |
| Phytoestrogens | 📋 | | ⛔ | | 35668938 | A Systematic Review and Meta-Analysis of Phytoestrogen Protects Against Myocardial Ischemia/Reperfusion Injury: Pre-Clinical Evidence From Small Animal Studies |
| Poria Mushrooms | 📋 | ✍ | | | 38212001 | [Effect and mechanism of Poria cocos polysaccharides on myocardial cell apoptosis in rats with myocardial ischemia-reperfusion injury by regulating Rho-ROCK signaling pathway] |
| Potato | 📋 | | ⛔ | | 36856829 | Prospective cohort study on potato intake and mortality from cardiovascular diseases: the Japan Collaborative Cohort Study (JACC study) |
| Prickly Pear | 📋 | | ⛔ | | 36569488 | Opuntia ficus indica (L.) fruit extract alleviates oxidative stress through activation of dual oxidases and Keap1/Nrf2 signaling cascades in high-fat-diet associated atherosclerosis rats |
| Prunella Vulgaris | 📋 | ✍ | ⛔ | | 37992723 | Phenolic acids from Prunella vulgaris alleviate cardiac remodeling following myocardial infarction partially by suppressing NLRP3 activation |
| Quinoa | 📋 | | ⛔ | | 37476690 | Glucolipid metabolism improvement in impaired glucose tolerance subjects consuming a Quinoa-based diet: a randomized parallel clinical trial |
| Rosavin | 📋 | | ⛔ | | 37254848 | Rosavin protects the blood-brain barrier against ischemia/reperfusion-induced cerebral injury by regulating MAPK-mediated MMPs pathway |
| Rosehip | 📋 | ✍ | ⛔ | | 38107098 | Protective effects of fruit extract of Rosa canina and quercetin on human umbilical vein endothelial cell injury induced by hydrogen peroxide |
| Sea Cucumber | 📋 | | | | 37105382 | Sea Cucumber Phospholipids Regulate Cholesterol Metabolism in High-Fat Diet-induced ApoE-/- Mice |
| Seaweeds | 📋 | | ⛔ | | 37405739 | Neuroprotective Potential of Brown Seaweed Phytochemicals in Rodent Models of Cerebral Ischemia |
| Sesame Oil | 📋 | | ⛔ | | 37116130 | Comparing the Effects of Sesame Oil vs. Nitroglycerin Ointment on the Incidence of Chemotherapy-Induced Phlebitis: A Single Blind Clinical Trial |
| Sodium Bicarbonate | 📋 | ✍ | ⛔ | | 37921685 | Sodium Bicarbonate and Calcium Chloride for the Treatment of Hyperkalemia-Induced Cardiac Arrest: A Randomized, Blinded, Placebo-Controlled Animal Study |
| Soy Protein | 📋 | ✍ | ⛔ | | 38174000 | Protein supplementation: the double-edged sword |
| Star Anise | 📋 | ✍ | ⛔ | | 35305622 | Anti-glycation properties of Illicium verum Hook. f. fruit in-vitro and in a diabetic rat model |
| Sunflower Oil | 📋 | ✍ | ⛔ | | 33749789 | Systemic administration of sunflower oil exerts neuroprotection in a mouse model of transient focal cerebral ischaemia |
| Thymol | 📋 | ✍ | ⛔ | | 32715125 | Cardioprotective effect of thymol against adrenaline-induced myocardial injury in rats |
| UDCA | 📋 | ✍ | ⛔ | | 38085723 | Evaluation of therapeutic effect of oral Ursodeoxycholic Acid on indirect hyperbilirubinemia in term neonates undergoing phototherapy: A randomized controlled clinical trial |
| Vitamin B5 | 📋 | ✍ | ⛔ | | 3590676 | [Therapeutic efficacy of pantothenic acid preparations in ischemic heart disease patients] |
| Witch Hazel | 📋 | ✍ | ⛔ | | 33683221 | The effect of sucralfate-containing ointment on quality of life in people with symptoms associated with haemorrhoidal disease and its complications: the results of the EMOCARE survey |
| Yam | 📋 | | | | 37453145 | UPLC-Q TOF-MS-Based metabolomics and anti-myocardial ischemia activity of Dioscoreae Nipponicae Rhizoma from different geographical origins |
| Yiang Yiang Essential Oil | 📋 | | ⛔ | | 38087747 | Effect of Lavandula angustifolia and Cananga odorata on decrease of blood pressure in high blood pressure volunteers: A randomized controlled trial |
| Yohimbine | 📋 | ✍ | | | 38466531 | Yohimbine Treatment Alleviates Cardiac Inflammation/Injury and Improves Cardiac Hemodynamics by Modulating Pro-Inflammatory and Oxidative Stress Indicators |
| Zeaxanthin | 📋 | ✍ | ⛔ | | 36913015 | Zearalenone induces the senescence of cardiovascular cells in vitro and in vivo |
| Amaranth | 📋 | | ⛔ | | 33101347 | Amaranth as a Source of Antihypertensive Peptides |
| Apricot Oil | 📋 | | ⛔ | | 21896302 | Protective Effects of Apricot Kernel Oil on Myocardium Against Ischemia-Reperfusion Injury in Rats |
| Arnica | 📋 | ✍ | ⛔ | | 36220097 | Neuroprotective Properties of Chlorogenic Acid and 4,5-Caffeoylquinic Acid from Brazilian arnica (Lychnophora ericoides) after Acute Retinal Ischemia |
| Bacopa Monnieri | 📋 | ✍ | ⛔ | | 15934019 | Antioxidant activity of DHC-1, an herbal formulation, in experimentally-induced cardiac and renal damage |
| Bean | 📋 | | ⛔ | | 36963901 | Beans comsumption can contribute to the prevention of cardiovascular disease |
| Bee Pollen | 📋 | ✍ | ⛔ | | 35796099 | Bee bread attenuates the progression of atherosclerosis by activating Nrf2/Keap1 and modulating TNF-α/NF-κβ-associated mast cell migration and a mitochondrial-dependent apoptotic pathway in the obese rat model |
| Beer | 📋 | | | | 36615830 | Features of Non-Alcoholic Beer on Cardiovascular Biomarkers. Can It Be a Substitute for Conventional Beer? |
| Black Pepper Essential Oil | 📋 | | ⛔ | | 25642050 | The effect of olfactory stimuli on the balance ability of stroke patients |
| Black Tea Polyphenols | 📋 | | | | 24172295 | Interactions of black tea polyphenols with human gut microbiota: implications for gut and cardiovascular health |
| Bok Choy | 📋 | | ⛔ | | 36249822 | Antihypertensive potential of Brassica rapa leaves: An in vitro and in silico approach |
| Bread | 📋 | | | | 36366944 | The impact of low-salt bread as a simple diet on hypertensive patients with cardiovascular comorbidities |
| Butter | 📋 | | ⛔ | | 37671505 | High consumption of dairy products and risk of major adverse coronary events and stroke in a Swedish population |
| Camphor | 📋 | ✍ | ⛔ | | 31255877 | The combination of hawthorn extract and camphor significantly increases blood pressure: A meta-analysis and systematic review |
| Cantaloupe | 📋 | | ⛔ | | 38348351 | Cardioprotective and hypotensive mechanistic insights of hydroethanolic extract of Cucumis melo L. kernels in isoprenaline-induced cardiotoxicity based on metabolomics and in silico electrophysiological models |
| Carbohydrates | 📋 | | | | 36364706 | Greater Protection of Lower Dietary Carbohydrate to Fiber Ratio (CFR) against Poor Blood Pressure Control in Patients with Essential Hypertension: A Cross-Sectional Study |
| Cashew | 📋 | | ⛔ | | 36578402 | Antihypertensive activity of roasted cashew nut in mixed petroleum fractions-induced hypertension: An in vivo and in silico approaches |
| Castor Oil | 📋 | ✍ | ⛔ | | 38696683 | Methanolic Extract of Ricinus Communis ameliorated cardiovascular dysfunction in dichlorvos-exposed rats |
| Chaga Mushrooms | 📋 | ✍ | ⛔ | | 33236154 | Inonotus obliquus extract alleviates myocardial ischemia/reperfusion injury by suppressing endoplasmic reticulum stress |
| Chondroitin | 📋 | ✍ | ⛔ | | 35923649 | Risk of ischaemic stroke among new users of glucosamine and chondroitin sulphate: a nested case-control study |
| Citral | 📋 | | | | 37210385 | Ginger essential oil and citral ameliorates atherosclerosis in ApoE-/- mice by modulating trimethylamine-N-oxide and gut microbiota |
| Citronella Essential Oil | 📋 | ✍ | ⛔ | | 35151650 | Citronellal alleviate macro- and micro-vascular damage in high fat diet / streptozotocin - Induced diabetic rats via a S1P/S1P1 dependent signaling pathway |
| Clary Sage Essential Oil | 📋 | ✍ | ⛔ | | 37141519 | [Impact of essential oil vapors inhalation on blood pressure in patients with hypertension] |
| Clove Essential Oil | 📋 | | ⛔ | | 37141519 | [Impact of essential oil vapors inhalation on blood pressure in patients with hypertension] |
| Coriander Essential Oil | 📋 | ✍ | ⛔ | | 37141519 | [Impact of essential oil vapors inhalation on blood pressure in patients with hypertension] |
| Deodar Cedar | 📋 | | | | 35325515 | Attenuation of cisplatin induced myelosuppression by methanol extract of Cedrus deodara in wistar rats |
| Diallyl Sulfide | 📋 | | | | 34651661 | Diallyl sulfide protects against dilated cardiomyopathy via inhibition of oxidative stress and apoptosis in mice |
| Eclipta Alba | 📋 | ✍ | | | 34627325 | A network pharmacology-based approach to explore the active ingredients and molecular mechanism of Lei-gong-gen formula granule on a spontaneously hypertensive rat model |
| Elastin | 📋 | ✍ | | | 34917605 | Elastin Structure, Synthesis, Regulatory Mechanism and Relationship With Cardiovascular Diseases |
| Emu Oil | 📋 | ✍ | ⛔ | | 26415675 | Emu oil decreases atherogenic plaque formation in cafeteria diet-induced obese rats |
| Fennel | 📋 | ✍ | ⛔ | | 38678740 | Fennel seeds extract prevents fructose-induced cardiac dysfunction in a rat model of metabolic syndrome via targeting abdominal obesity, hyperuricemia and NF-κβ inflammatory pathway |
| Fennel Essential Oil | 📋 | ✍ | ⛔ | | 17709257 | Protective effect of Foeniculum vulgare essential oil and anethole in an experimental model of thrombosis |
| Fermented Foods | 📋 | | ⛔ | | 36204374 | Fermented foods and cardiometabolic health: Definitions, current evidence, and future perspectives |
| Genipin | 📋 | | | | 36445232 | POTENTIAL CARDIOPROTECTIVE EFFECT OF GENIPIN VIA CYCLOOXIDASE 2 SUPPRESSION AND P53 SIGNAL PATHWAY ATTENUATION IN INDUCED MYOCARDIAL INFARCTION IN RATS |
| Giloy | 📋 | ✍ | ⛔ | | 37907489 | Cardioprotective Role of Tinospora cordifolia against Trimethylamine-NOxide and Glucose Induced Stress in Rat Cardiomyocytes |
| Ginger Essential Oil | 📋 | ✍ | | | 37210385 | Ginger essential oil and citral ameliorates atherosclerosis in ApoE-/- mice by modulating trimethylamine-N-oxide and gut microbiota |
| Guggul | 📋 | ✍ | ⛔ | | 33825411 | Efficacy and safety of Hemoheal cream in patients with hemorrhoids: a randomized double-blind placebo controlled clinical trial |
| Haskap | 📋 | | | | 19572653 | Protectivity of Blue Honeysuckle Extract Against Oxidative Human Endothelial Cells and Rat Hepatocyte Damage |
| Honeysuckle | 📋 | | ⛔ | | 35594639 | Lonicerae japonicae flos ameliorates radiotherapy-induced mesenteric artery endothelial dysfunction through GTPCH1/BH 4/eNOS pathway |
| Horsetail Grass | 📋 | ✍ | ⛔ | | 35168030 | Antihypertensive effect of Equisetum arvense L.: a double-blind, randomized efficacy and safety clinical trial |
| Iodine | 📋 | ✍ | ⛔ | | 33559332 | Efficacy of topical cadexomer iodine treatment in chronic wounds: Systematic review and meta-analysis of comparative clinical trials |
| Kacip Fatimah | 📋 | ✍ | ⛔ | | 25786162 | Protective effects of Labisia pumila var. alata on biochemical and histopathological alterations of cardiac muscle cells in isoproterenol-induced myocardial infarction rats |
| Kimchi | 📋 | | ⛔ | | 35840231 | Kimchi intake alleviates obesity-induced neuroinflammation by modulating the gut-brain axis |
| Kombucha | 📋 | ✍ | ⛔ | | 37402035 | Chronic Kombucha Beverage Consumption Attenuates Inflammatory Markers and Histopathology of Brain Tissue in Transnet Global Brain Ischemia in Rats |
| L-Alanine | 📋 | ✍ | ⛔ | | 33626855 | Extremely Low Serum Alanine Transaminase Level Is Associated with All-Cause Mortality in the Elderly after Intracranial Hemorrhage |
| L-Proline | 📋 | ✍ | ⛔ | | 32492448 | Proline Improves Cardiac Remodeling Following Myocardial Infarction and Attenuates Cardiomyocyte Apoptosis via Redox Regulation |
| Lauric Acid | 📋 | ✍ | | | 37572940 | Lauric acid provides neuroprotection against oxidative stress in mouse model of hyperglycaemic stroke |
| Leek | 📋 | | ⛔ | | 33825411 | Efficacy and safety of Hemoheal cream in patients with hemorrhoids: a randomized double-blind placebo controlled clinical trial |
| Lemon Essential Oil | 📋 | ✍ | ⛔ | | 21157172 | [Effects of aromatherapy on changes in the autonomic nervous system, aortic pulse wave velocity and aortic augmentation index in patients with essential hypertension] |
| Lemongrass Essential Oil | 📋 | ✍ | ⛔ | | 38639827 | Cardioprotective Potential of Cymbopogon citratus Essential Oil against Isoproterenol-induced Cardiomyocyte Hypertrophy: Possible Involvement of NLRP3 Inflammasome and Oxidative Phosphorylation Complex Subunits |
| Lettuce | 📋 | | ⛔ | | 35871120 | Double-blind controlled dietary cross-over intervention with differentially fertilised intact lettuce leaves shows acute reduction in blood pressure in young adults, associated with faster uptake of nitrate than of phenolics |
| Malvidin | 📋 | | | | 27034731 | Effect of Blueberry Anthocyanins Malvidin and Glycosides on the Antioxidant Properties in Endothelial Cells |
| Milk Thistle | 📋 | ✍ | ⛔ | | 33857761 | Triglyceride-induced cardiac lipotoxicity is mitigated by Silybum marianum |
| Mint | 📋 | | ⛔ | | 35759866 | Ex vivo, in vitro, and in silico approaches to unveil the mechanisms underlying vasorelaxation effect of Mentha Longifolia (L.) in porcine coronary artery |
| Morusin | 📋 | | | | 38502885 | Morusin Alleviates Aortic Valve Calcification by Inhibiting Valve Interstitial Cell Senescence Through Ccnd1/Trim25/Nrf2 Axis |
| Mucuna Pruriens | 📋 | ✍ | ⛔ | | 36875022 | Effect of Mucuna pruriens on brain NMDA receptor and tau protein gene expression in cerebral ischemic rats |
| MUFA | 📋 | | ⛔ | | 26016869 | Replacement of saturated with unsaturated fats had no impact on vascular function but beneficial effects on lipid biomarkers, E-selectin, and blood pressure: results from the randomized, controlled Dietary Intervention and VAScular function (DIVAS) study |
| Mushrooms | 📋 | | ⛔ | | 37157920 | Edible mushrooms as potential functional foods in amelioration of hypertension |
| Myrrh | 📋 | ✍ | ⛔ | | 35082676 | Combination of Systems Pharmacology and Experimental Evaluation to Explore the Mechanism of Synergistic Action of Frankincense-Myrrh in the Treatment of Cerebrovascular Diseases |
| Myrtle Essential Oil | 📋 | ✍ | ⛔ | | 28844211 | Effectiveness of Myrtus communis in the treatment of hemorrhoids |
| Neem | 📋 | ✍ | | | 33244247 | Evaluation of the Effect of an Aqueous Extract of Azadirachta indica (Neem) Leaves and Twigs on Glycemic Control, Endothelial Dysfunction and Systemic Inflammation in Subjects with Type 2 Diabetes Mellitus - A Randomized, Double-Blind, Placebo-Controlled Clinical Study |
| Neem Oil | 📋 | ✍ | ⛔ | | 30993302 | Treatment of Peristomal granulomatosis with a Neem and Red Hypericum Oil application: Case studies |
| Nutmeg | 📋 | ✍ | ⛔ | | 33434281 | Myristica fragrans promotes ABCA1 expression and cholesterol efflux in THP-1-derived macrophages |
| Oyster | 📋 | | ⛔ | | 37960326 | Oral Zinc-Rich Oyster Supplementation Corrects Anemia in Rats |
| Oyster Mushrooms | 📋 | | ⛔ | | 19083429 | Antiatherosclerotic effect of the edible mushrooms Pleurotus eryngii (Eringi), Grifola frondosa (Maitake), and Hypsizygus marmoreus (Bunashimeji) in apolipoprotein E-deficient mice |
| Pantethine | 📋 | ✍ | ⛔ | | 6442152 | Pantethine reduces plasma cholesterol and the severity of arterial lesions in experimental hypercholesterolemic rabbits |
| Parsley | 📋 | | ⛔ | | 34012875 | Oral treatment with a chemically characterized parsley ( Petroselinum crispum var . neapolitanum Danert) aqueous extract reduces thrombi formation in rats |
| Peach | 📋 | | ⛔ | | 25801980 | Consumption of polyphenol-rich peach and plum juice prevents risk factors for obesity-related metabolic disorders and cardiovascular disease in Zucker rats |
| Peas | 📋 | | ⛔ | | 34649330 | Pea (Pisum sativum) peel extract attenuates DOX-induced oxidative myocardial injury |
| Pelargonidin | 📋 | | | | 33552591 | Pelargonidin ameliorates MCAO-induced cerebral ischemia/reperfusion injury in rats by the action on the Nrf2/HO-1 pathway |
| Pineapple | 📋 | ✍ | ⛔ | | 36062986 | Pineapple fruit improves vascular endothelial dysfunction, hepatic steatosis, and cholesterol metabolism in rats fed a high-cholesterol diet |
| Protein | 📋 | ✍ | ⛔ | | 36904253 | High Protein Intake at Lunch Is Negatively Associated with Blood Pressure in Community-Dwelling Older Adults: A Cross-Sectional Study |
| Pumpkin Seed | 📋 | ✍ | ⛔ | | 18938206 | Hypolipidemic and hepatoprotective effects of flax and pumpkin seed mixture rich in omega-3 and omega-6 fatty acids in hypercholesterolemic rats |
| Radish | 📋 | | ⛔ | | 35794452 | Polyacylated Anthocyanins Derived from Red Radishes Protect Vascular Endothelial Cells Against Palmitic Acid-Induced Apoptosis via the p38 MAPK Pathway |
| Rose Essential Oil | 📋 | | | | 35728707 | Geraniol and β-citronellol participate in the vasorelaxant effects of Rosa damascena Miller essential oil on the rat thoracic aorta |
| Sardine | 📋 | | ⛔ | | 36860672 | Cardiovascular and lipid-lowering effects of a marine lipoprotein extract in a high-fat diet-induced obesity mouse model |
| Sesamolin | 📋 | | | | 30606956 | Sesame Extract Attenuates the Degradation of Collagen and Elastin Fibers in the Vascular Walls of Nicotine-administered Mice |
| Shilajit | 📋 | ✍ | ⛔ | | 24448712 | Cardioprotective effect of mumie (shilajit) on experimentally induced myocardial injury |
| St. Johns Wort Oil | 📋 | | ⛔ | | 30993302 | Treatment of Peristomal granulomatosis with a Neem and Red Hypericum Oil application: Case studies |
| Sugarcane | 📋 | | ⛔ | | 38027563 | Sugarcane leaf polysaccharide exerts a therapeutic effect on cardiovascular diseases through necroptosis |
| Sunflower | 📋 | | ⛔ | | 34521318 | Helianthus Annuus L. Alleviates High-Fat Diet Induced Atherosclerosis by Regulating Intestinal Microbiota, Inhibiting Inflammation and Restraining Oxidative Stress |
| Tamarind | 📋 | | ⛔ | | 37571339 | Sour Tamarind Is More Antihypertensive than the Sweeter One, as Evidenced by In Vivo Biochemical Indexes, Ligand-Protein Interactions, Multitarget Interactions, and Molecular Dynamic Simulation |
| Tangerine | 📋 | | ⛔ | | 35100035 | Effects of Citrus depressa Hayata Fruit Extract on Thigh Muscles Mass and Composition in Subacute Stroke Patients: A Double-Blind, Randomized, Controlled Pilot Trial |
| Tea Tree Essential Oil | 📋 | | ⛔ | | 22492249 | Efficacy and tolerability of hyaluronic acid, tea tree oil and methyl-sulfonyl-methane in a new gel medical device for treatment of haemorrhoids in a double-blind, placebo-controlled clinical trial |
| Thyme Essential Oil | 📋 | | ⛔ | | 36337844 | The Effect of Thyme Essential Oil on Liver Injuries Caused by Renal Ischemia-Reperfusion in Rats |
| Tongkat Ali | 📋 | ✍ | ⛔ | | 27800486 | First Report of Eurycoma longifolia Jack Root Extract Causing Relaxation of Aortic Rings in Rats |
| Turkey Tail Mushrooms | 📋 | | ⛔ | | 37375735 | Characterization, In Vitro Biological Activity and In Vivo Cardioprotective Properties of Trametes versicolor (L.:Fr.) Quél. Heteropolysaccharides in a Rat Model of Metabolic Syndrome |
| Vitex | 📋 | ✍ | ⛔ | | 35360656 | Vasorelaxant Effects of the Vitex Agnus-Castus Extract |
| Wasabi | 📋 | | ⛔ | | 36360048 | Wasabi ( Eutrema japonicum) Reduces Obesity and Blood Pressure in Diet-Induced Metabolic Syndrome in Rats |
| White Mushrooms | 📋 | | ⛔ | | 31162580 | Edible Mushrooms Reduce Atherosclerosis in Ldlr-/- Mice Fed a High-Fat Diet |
| Withanolides | 📋 | | | | 34090907 | Standardized root extract of Withania somnifera and Withanolide A exert moderate vasorelaxant effect in the rat aortic rings by enhancing nitric oxide generation |
| Wood Ear Mushrooms | 📋 | | ⛔ | | 35467804 | Human Hemoglobin S Erythrocyte-Stabilizing and Antisickling Potential of Extract of Wood Ear Mushroom, Auricularia auricula (Agaricomycetes) |
| Yerba Mate | 📋 | ✍ | ⛔ | | 35373729 | Multigenomic modifications in human circulating immune cells in response to consumption of polyphenol rich extract of yerba mate ( Ilex paraguariensis A. St.-Hil.) are suggestive of cardiometabolic protective effects |
